Humoral immunity in late-onset Pre-eclampsia and linkage with angiogenic and inflammatory markers

American Journal of Reproductive Immunology : AJRI
Nadia SarweenGraham W Lipkin

Abstract

Pre-eclampsia (PE) is a leading cause of maternal and foetal morbidity worldwide. Given the implication of immune mechanisms, we compared markers of humoral immunity in PE and their relationship to circulating markers of inflammation, angiogenic factors, and renal function. Serum samples from 88 previously healthy women admitted to hospital with PE and 107 healthy pregnant controls at term were analysed for serum immunoglobulins (Ig), including IgG subclasses and free light chain (sFLC) levels, beta-2 microglobulin (B2-M), high-sensitivity C-reactive protein (HS-CRP), albumin, complement proteins (C3 & C4), creatinine, cystatin-C and the ratio of soluble fms-like tyrosine kinase-1 (sFLT-1) and placental growth factor (PlGF). Compared to the controls, women with PE had significantly reduced renal function, serum IgG (subclass 1 & 3), albumin, and C4 levels, whilst concentrations of total sFLC, HS-CRP, B2-M, and sFLT-1:PlGF were raised. On multivariable analysis, sFLT-1:PlGF ratio (P < 0.001), sFLC (P < 0.001) and IgG1 (P < 0.024) were found to be independently associated with PE, after accounting for renal function, patient age, BMI, ethnicity, and parity. B2-M and sFLT-1:PlGF had comparable diagnostic association with PE (P = 0...Continue Reading

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Citations

Jan 24, 2019·American Journal of Reproductive Immunology : AJRI·Julie Brogaard LarsenAnette Tarp Hansen
Jun 12, 2020·Immunological Investigations·Cecilia NapodanoUmberto Basile
Jan 23, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ali OvayoluErbil Karaman
Feb 9, 2021·Human Immunology·Ai-Ris Y CollierS Ananth Karumanchi
Nov 22, 2020·International Journal of Molecular Sciences·Loredana AlboniciRoberto Bei
Apr 3, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Juilee S DeshpandeSadhana R Joshi

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