PMID: 708932Sep 1, 1978Paper

Humoral immunity in mice following oral administration of selected pesticides

Bulletin of Environmental Contamination and Toxicology
R W WiltroutW S Ceglowski

Abstract

Five pesticides (carbaryl, DDT, parathion, chlordimeform, and ametryne) were tested for their effects on the immunocompetence of Balb/c mice. All five of the test pesticides were observed to induce statistically significant suppression of the humoral immune response if administered orally, at near lethal doses, during an ongoing immune response. Ametryne and chlordimeform were also observed to have a suppressive effect on humoral immune competence if orally administered in a sufficiently large quantity, 1 LD50, at the time of, or prior to, immunization. Administration of 0.1 LD50 parathion per day, over an extended period of time, resulted in a statistically significant suppression of the humoral immune response.

References

Sep 1, 1971·Bulletin of Environmental Contamination and Toxicology·M WassermannM Djavaherian
Jan 1, 1969·Annals of the New York Academy of Sciences·J Gabliks, L Friedman
Feb 1, 1973·Mutation Research·F Kelly-Garvert, M S Legator
Sep 1, 1973·Journal of the National Cancer Institute·V TurusovR T Charles
Nov 1, 1972·International Journal of Cancer. Journal International Du Cancer·L TomatisR T Charles
Jan 1, 1969·Annals of the New York Academy of Sciences·M WassermannL Zellermayer
May 1, 1969·Toxicology and Applied Pharmacology·T B Gaines
Oct 1, 1964·Archives of Environmental Health·T H MILBY, W L EPSTEIN
Apr 26, 1963·Science·N K Jerne, A A Nordin

Citations

Jul 1, 1987·Archives of Environmental Contamination and Toxicology·L J OlsonE V Nordheim
Sep 1, 1986·Bulletin of Environmental Contamination and Toxicology·B D BanerjeeQ Z Hussain
Jul 1, 1992·International Journal of Immunopharmacology·D FlipoM Fournier
Nov 1, 1984·Toxicology Letters·G P CasaleR A DiCapua
Feb 1, 1987·Toxicology Letters·J BernierM Fournier
Nov 6, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Lokesh K SinghalR S Chauhan
Jan 1, 1983·Journal of Toxicology and Environmental Health·A L AllenG A Pollock
Jan 1, 1988·Journal of Toxicology and Environmental Health·M FournierK Krzystyniak
Jun 1, 1981·Environmental Health Perspectives·J B Silkworth, L D Loose
Dec 30, 2014·Indian Journal of Pharmacology·Suprita Sinha, A M Thaker
Oct 30, 2008·Journal of Immunotoxicology·O N OfordileS D Holladay
May 5, 2012·Environmental Toxicology and Pharmacology·Syamantak Mani TripathiLaxmi Narayan Sankhala
Oct 11, 2015·Pesticide Biochemistry and Physiology·Ines El-Bini DhouibSaloua El-Fazaa
Dec 1, 1986·Environmental Research·M C FioreD Belluck
Feb 24, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H S Elsabbagh, O S El-Tawil
Apr 3, 1999·Toxicology and Industrial Health·I VocciaM Fournier
Jul 24, 2001·Journal of Occupational and Environmental Medicine·T ZhengA Blair
Sep 4, 2008·Journal of Neurosurgery. Spine·Jason L SchroederBruce E Mathern
Sep 1, 1988·Toxicology and Industrial Health·P T Thomas, H V Ratajczak
Oct 28, 2017·Frontiers in Chemistry·Nitika SinghBechan Sharma

Related Concepts

Antibody Formation
Lethal Dose 50
Mice, Inbred BALB C
Pesticides

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