Humoral immunity in stage I mycosis fungoides: an increased incidence of lymphocytotoxic antibodies

The British Journal of Dermatology
A L SchocketD A Norris

Abstract

Thirteen patients with stage I mycosis fungoides (MF) were studied for the presence of circulating autoantibodies including cold-reactive lymphocytotoxic antibodies (LCA), antinuclear antibodies and rheumatoid factor antibodies to common food antigens, bovine gamma globulin and casein; and immune complexes as measured by cryoglobulins and I125 Clq binding. A significantly increased incidence (11/13) of LCA was found in the MF patients, and this may be related to the alterations in subpopulations of T cells seen in these patients. No significant increase in any other test was noted. there was no evidence of a diffuse hyperactivity of the humoral immune system as seen in systemic lupus erythematosus, which has a similar imbalance of T cell subpopulations.

References

Oct 1, 1979·Arthritis and Rheumatism·A L Schocket, P F Kohler
Dec 1, 1976·The Journal of Clinical Investigation·S BroderT A Waldmann
Nov 1, 1978·Arthritis and Rheumatism·R L RubinR I Carr
Feb 1, 1976·Annals of Internal Medicine·J R MendiusR C Williams
Jul 1, 1976·Arthritis and Rheumatism·I MalavéZ Layrisse
Sep 1, 1976·Clinical Immunology and Immunopathology·N I AbdouS Sadeghee
Mar 1, 1975·Annals of Internal Medicine·J L DeckerS A Paget
Jun 1, 1975·The Journal of Clinical Investigation·R J DeHoratius, R P Messner
Dec 7, 1975·The New England Journal of Medicine·S J KorsmeyerR G Strickland
Aug 16, 1973·The New England Journal of Medicine·J C BrouetM Seligmann
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D Zucker-FranklinF Quagliata
Dec 1, 1974·The British Journal of Dermatology·R S TanP D Samman
May 1, 1973·The Journal of Clinical Investigation·S W HuangR Hong
Oct 1, 1970·The New England Journal of Medicine·P I TerasakiE V Barnett
Mar 28, 1970·Nature·K K MittalW T Butler
Nov 1, 1970·Transplantation·M J KreislerP I Terasaki
Dec 5, 1964·Nature·P I TERASAKI, J D MCCLELLAND

❮ Previous
Next ❯

Citations

Sep 17, 1998·Journal of the American Academy of Dermatology·S R PetersonM Duvic
Jun 1, 1988·The British Journal of Dermatology·K Thestrup-PedersenH Zachariae

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.