Humoral immunity through immunoglobulin M protects mice from an experimental actinomycetoma infection by Nocardia brasiliensis

Infection and Immunity
M C Salinas-Carmona, Isabel Pérez-Rivera

Abstract

An experimental model of infection with Nocardia brasiliensis, used as an example of a facultative intracellular pathogen, was tested. N. brasiliensis was injected into the rear foot pads of BALB/c mice to establish an infection. Within 30 days, infected animals developed a chronic actinomycetoma infection. Batch cultures of N. brasiliensis were used to purify P61, P38, and P24 antigens; P61 is a catalase, and P38 is a protease with strong caseinolytic activity. Active and passive immunizations of BALB/c mice with these three purified soluble antigens were studied. Protection was demonstrated for actively immunized mice. However, immunity lasted only 30 days. Other groups of immunized mice were bled at different times, and their sera were passively transferred to naive recipients that were then infected with N. brasiliensis. Sera collected 5, 6, and 7 days after donor immunization conferred complete, long-lasting protection. The protective effect of passive immunity decreased when sera were collected 2 weeks after donor immunization. However, neither the early sera (1-, 2-, and 3-day sera) nor the later sera (30- or 45-day sera) prevented the infection. Hyperimmune sera with the highest levels of immunoglobulin G (IgG) to N. br...Continue Reading

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Citations

Jul 25, 2012·Antonie van Leeuwenhoek·Mario Cesar Salinas-CarmonaOliverio Welsh
Oct 16, 2010·Nature Reviews. Immunology·Michael R Ehrenstein, Clare A Notley
Feb 24, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mario C Salinas-CarmonaAnna V Vázquez-Marmolejo
May 15, 2007·Current Opinion in Infectious Diseases·Abdalla A O AhmedAlex van Belkum
May 2, 2012·Infection and Immunity·Adrian G Rosas-TaracoMario C Salinas-Carmona
Jan 8, 2016·The Lancet Infectious Diseases·Eduard E ZijlstraAhmed H Fahal
Jun 12, 2012·Clinics in Dermatology·Oliverio WelshMario Cesar Salinas
Jun 12, 2012·Clinics in Dermatology·Lucio Vera-CabreraOliverio Welsh
Jun 23, 2009·Immunology Letters·Rachael Racine, Gary M Winslow
Mar 14, 2007·Clinics in Dermatology·Oliverio WelshMario Cesar Salinas-Carmona
Feb 1, 2009·Evolutionary Applications·Karen J Fairlie-ClarkeAndrea L Graham
Dec 3, 2014·Seminars in Immunology·John ChanJoAnne Flynn
Jul 25, 2009·FEMS Immunology and Medical Microbiology·Maria L Gonzalez-SuarezIsabel Pérez-Rivera
Sep 8, 2016·Journal of Immunoassay & Immunochemistry·Tsuyoshi ToriiAkeo Hagiwara
Dec 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachael RacineGary M Winslow
Nov 16, 2018·The Journal of Experimental Medicine·Guilhem R ThierryMarc Bajénoff
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bhargavi RajanThiruchandurai V Rajan
Oct 23, 2020·PLoS Neglected Tropical Diseases·Mario C Salinas-CarmonaAnna Velia Vázquez-Marmolejo
Oct 6, 2020·Pathogens and Disease·Mayra A Rodríguez-SerratoAlberto Yairh Limón-Flores
May 7, 2021·FEMS Microbiology Letters·Anna V Vazquez-MarmolejoMario C Salinas-Carmona

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