Humoral Immunity to Hantavirus Infection.

MSphere
Taylor B Engdahl, James E Crowe

Abstract

Hantaviruses are zoonotic pathogens found in parts of Europe, Asia, South America, and North America, which can cause renal and respiratory failure with fatality rates up to 40%. There are currently no FDA-approved vaccines or therapeutics for hantavirus-related diseases; however, it is evident that a robust neutralizing antibody response is critical for protection from severe disease. Although virologists first described this family of viruses in the 1950s, there is limited information on the neutralizing epitopes that exist on the hantavirus antigenic glycoproteins, Gn and Gc, and sites important for the design of effective therapeutics and vaccines. We provide a thorough summary of the hantavirus field from an immunological perspective. In particular, we discuss our current structural knowledge of antigenic proteins Gn and Gc, identification of B cell neutralizing epitopes, previously isolated monoclonal antibodies and their cross-reactivity between different hantavirus strains, and current developments toward vaccines and therapeutics. We conclude with some outstanding questions in the field and emphasize the need for additional studies of the human antibody response to hantavirus infection.IMPORTANCE Hantaviruses are patho...Continue Reading

References

Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M C FrankoD C Gajdusek
Nov 1, 1996·The Journal of General Virology·A PlyusninA Vaheri
May 1, 1997·Journal of Virology·T HeiskanenH Lankinen
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·I N GavrilovskayaE R Mackow
Nov 24, 1999·Journal of Medical Virology·D J McClainC S Schmaljohn
Jul 7, 2000·The Journal of Infectious Diseases·M BharadwajB Hjelle
Apr 23, 2003·Virology·Joachim KochEkkehard K F Bautz
Mar 23, 2005·Virology·Nicole D TischlerPablo D T Valenzuela
Oct 18, 2005·The Journal of General Virology·Nicole D TischlerPablo D T Valenzuela
Feb 21, 2006·Emerging Infectious Diseases·Valeria P MartinezPaula J Padula
Feb 24, 2006·Emerging Infectious Diseases·Francisca ValdiviesoBrian Hjelle
Oct 16, 2009·Journal of Virology·Jussi HepojokiHilkka Lankinen
Feb 26, 2010·Journal of Virology·Irina N GavrilovskayaErich R Mackow
Nov 12, 2010·Journal of Virology·Anthony J BattistiMichael G Rossmann
Dec 15, 2012·Clinical and Vaccine Immunology : CVI·R L BrocatoJ W Hooper
Jun 8, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L PetterssonC Ahlm
Jan 23, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J W HooperC Schmaljohn
Dec 3, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Detlev H KrugerBoris Klempa
Apr 28, 2016·Cell Reports·Sai LiThomas A Bowden
May 24, 2016·Viruses·Amelina AlbornozNicole D Tischler
Jul 16, 2016·PLoS Neglected Tropical Diseases·Gonzalo P BarrigaNicole D Tischler

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Methods Mentioned

BETA
phage display

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