Humoral immunological profile and parasitological statuses of Leishmune vaccinated and visceral leishmaniasis infected dogs from an endemic area

Veterinary Parasitology
Izabela F G de AmorimA P da Costa-Val

Abstract

Dogs represent the major reservoir of Leishmaniao chagasi and vaccination against the canine disease is a potential control strategy. However, seroconversion occurs post-vaccine and hence, there is need to discriminate between the former group and naturally infected dogs. The present study represents a comparison of the humoral immunological profiles of both groups using Leishmania soluble antigen (LSA) and fucose-mannose ligand (FML). For both categories, ear skin samples were evaluated immunohistochemically and through PCR, that was also performed in blood specimens, as well as their ability to infect Lutzomyia (Lutzomyia) longipalpis. All these tests showed negative results for the vaccinated dogs. Differences between groups were observed regarding IgG, IgG2 and IgE absorbances as determined by FML-ELISA, and for IgG1 and IgE absorbances as measured by LSA-ELISA, showing that Leishmune-immunised animals and VL naturally infected dogs present different immunological profiles, even though these differences cannot be used to distinguish between these two groups of dogs.

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Citations

Apr 29, 2014·International Journal of Experimental Pathology·Carolina C SouzaWagner L Tafuri
Mar 19, 2014·Veterinary Parasitology·Manolis K ChatzisManolis N Saridomichelakis
May 3, 2011·Veterinary Parasitology·Mary MarcondesAlexander W Biondo
Jan 30, 2015·Advances in Preventive Medicine·Faeze Foroughi-Parvar, Gholamreza Hatam
Dec 4, 2014·Revista Da Sociedade Brasileira De Medicina Tropical·Kalidia Felipe de Lima CostaThais Aparecida Kazimoto
Sep 4, 2018·Infectious Diseases of Poverty·Marcus EderCelina Maria Turchi Martelli
Feb 9, 2020·Tropical Medicine & International Health : TM & IH·Rita Velez, Montserrat Gállego
Sep 12, 2014·Revista de saúde pública·Daniela Farias LaranjeiraMárcia Dalastra Laurenti
Nov 26, 2020·Acta Cirúrgica Brasileira·Raquel de Oliveira MeiraLuiz Ronaldo Alberti

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