Humoral mechanisms in T cell vaccination: induction and functional characterization of anti-lymphocytic autoantibodies

Journal of Autoimmunity
J HerkelA Lohse

Abstract

T cell vaccination, the application of syngeneic attenuated T cells, has been shown to prevent effectively and treat experimental autoimmune diseases, but its mechanisms of action are poorly understood. Here we present data on the induction of a humoral anti-T cell response by T cell vaccination, capable of strongly inhibiting T cell proliferation and of ameliorating experimental autoimmune disease. T cell vaccination in the Lewis rat induced autoantibodies reactive with several syngeneic T cell proteins. These autoantibodies were not detectable in normal Lewis sera as assessed by immunoblotting and flow cytometry with intact syngeneic T cells. The autoantibody reactivity was not restricted to one idiotype, was detected as early as 1 week after vaccination and was dominated by IgG, suggesting the boosting of a naturally preformed humoral network by T cell vaccination. Recovery from passively or actively induced experimental autoimmune encephalomyelitis (EAE) in the Lewis rat, too, could be shown to be associated with the development of anti-T cell autoantibodies. In vitro, both the post-EAE and the post-vaccination sera had a strong suppressive effect on the proliferation of syngeneic T cell clones. This inhibition was shown to...Continue Reading

Citations

Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A W LohseK H Meyer zum Büschenfelde
Jul 13, 2004·Autoimmunity Reviews·Niels HellingsPiet Stinissen
Mar 1, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Luiz Stark Aroeira
Jul 15, 2009·Journal of Autoimmunity·Takao FujiiTsuneyo Mimori
Sep 1, 2006·Expert Review of Clinical Immunology·Niels HellingsPiet Stinissen
Aug 25, 2005·Expert Review of Vaccines·Sylvia Cohen-Kaminsky, Florence Jambou
Aug 16, 2008·The American Journal of Gastroenterology·Bo ShenVictor W Fazio
Mar 24, 2000·Journal of Autoimmunity·M Feili-HaririP A Morel

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