PMID: 1212411Oct 1, 1975Paper

Humoral mediated macrophage response during tumour growth

British Journal of Cancer
T M Saba, T G Antikatzides

Abstract

Reticuloendothelial (RE) phagocytic and circulating plasma opsonic activity was evaluated in rats transplanted with the Walker 256 carcinoma tumour in an attempt to evaluate the role of opsonic protein in governing the functional state of the macrophage system. Animals transplanted intramuscularly with 2 X 10(4) viable tumour cells manifested 2 peaks of RE stimulation at 6 and 14 days post-transplantation with a subsequent decline in the phagocytic activity over the 14-30 day period. Increased phagocytic activity as determined by colloid clearance was primarily a reflection of hepatic Küpffer cell hyperphagocytosis while the decline in phagocytic activity was related to a decrease in Küpffer cell function. The initial peak of RE stimulation was associated with an elevation in the blood opsonin level and no significant enlargement of the liver and spleen. In contrast, the second peak of RE stimulation at 14 days was associated with both an elevation in opsonin levels and an associated hepatic and splenic enlargement. The decline in phagocytic activity over the 14-30 day interval was associated with a progressive decline in the plasma opsonic activity, a return of the spleen to its normal size in relationship to the body weight, ...Continue Reading

Citations

Jul 15, 1980·International Journal of Cancer. Journal International Du Cancer·D Glaves
Jul 1, 1980·Journal of Biomedical Materials Research·M B Habal, R D Powell
Dec 29, 2015·Basic & Clinical Pharmacology & Toxicology·Larissa Favaretto GaluppoAlexandra Acco
Oct 1, 1984·The American Journal of Medicine·G Zerlauth, G Wolf

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