Humoral response to EBV is associated with cortical atrophy and lesion burden in patients with MS

Neurology. Neuroimmunology and Neuroinflammation
R ZivadinovM Ramanathan

Abstract

Because dysregulated Epstein-Barr virus (EBV)-infected B cells may induce meningeal inflammation, which contributes to cortical pathology in multiple sclerosis (MS), we investigated associations between antibody responses to EBV and development of cortical pathology in MS. We included 539 patients with MS (369 with relapsing-remitting MS, 135 with secondary progressive MS, and 35 with primary progressive MS), 66 patients with clinically isolated syndrome (CIS), 63 patients with other neurologic diseases (OND), and 178 age- and sex-matched healthy controls (HC). All participants were scanned on 3T MRI. Serum samples were analyzed for IgG antibodies against EBV viral capsid antigen (VCA) and EBV nuclear antigen-1 (EBNA-1), and their quartiles were determined on the whole study sample. Differences between the study groups were assessed using analysis of covariance adjusted for multiple comparisons. More than 30% of patients with MS and CIS presented with the highest quartile of anti-EBV-VCA and -EBNA-1 status compared to ≤10% of HC (p < 0.001). The figures were 9 (14.3%) and 7 (12.3%) for patients with OND. Patients with MS with the highest quartile of anti-EBV-VCA showed significantly increased T2 lesion volume (p = 0.001), T1 le...Continue Reading

References

Mar 17, 2000·Neurology·J H SimonN Simonian
Oct 30, 2001·Behavioural Brain Research·Y BenjaminiI Golani
Dec 17, 2002·NeuroImage·Stephen M SmithNicola De Stefano
Sep 20, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·D BuljevacR Q Hintzen
Oct 19, 2005·Brain : a Journal of Neurology·Alexandra KutzelniggHans Lassmann
Nov 7, 2007·The Journal of Experimental Medicine·Barbara SerafiniFrancesca Aloisi
Jan 21, 2009·Multiple Sclerosis : Clinical and Laboratory Research·T R NielsenH Hjalgrim
Jan 27, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·R ZivadinovM Ramanathan
Aug 15, 2009·Journal of Neuropathology and Experimental Neurology·Evert-Jan KooiPaul van der Valk
Sep 16, 2009·Archives of Neurology·Massimiliano CalabreseMassimo Filippi
Aug 13, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·R M LucasM P Pender
Nov 15, 2011·Neurology·A GiorgioN De Stefano
Dec 14, 2011·The New England Journal of Medicine·Claudia F LucchinettiRichard M Ransohoff
Aug 22, 2012·Multiple Sclerosis : Clinical and Laboratory Research·M FilippiM A Rocca
Dec 18, 2012·Journal of Neuropathology and Experimental Neurology·Roberta MagliozziFrancesca Aloisi
May 21, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Silje KvistadOivind Torkildsen

❮ Previous
Next ❯

Citations

Apr 23, 2016·Expert Review of Neurotherapeutics·Robert ZivadinovNiels Bergsland
Nov 5, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Robert ZivadinovBianca Weinstock-Guttman
Jul 22, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Linda RolfRaymond Hupperts
Jul 2, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Michael G DwyerRobert Zivadinov
Feb 6, 2020·Vaccines·Dejan JakimovskiRobert Zivadinov
Apr 18, 2020·Neurology·Marianna CorteseUNKNOWN BENEFIT Study Group
Feb 20, 2016·Neurology. Neuroimmunology and Neuroinflammation·Josep Dalmau
Jul 1, 2017·Expert Opinion on Biological Therapy·Dejan JakimovskiRobert Zivadinov
Nov 6, 2020·Expert Review of Clinical Immunology·Klemens Ruprecht
Jul 27, 2021·Frontiers in Immunology·Caterina Veroni, Francesca Aloisi

❮ Previous
Next ❯

Software Mentioned

SIENAX
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
J William LindseyT Vu
Multiple Sclerosis : Clinical and Laboratory Research
Jonatan SalzerPeter Sundström
Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceské lékarské spolecnosti J.E. Purkyne
A Bucková
© 2022 Meta ULC. All rights reserved