PMID: 7540060Apr 1, 1995Paper

Humoral response to Mycobacterium tuberculosis-specific antigens in African tuberculosis patients with high prevalence of human immunodeficiency virus infection

Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
S ThyboA B Andersen

Abstract

The applicability of serodiagnosis of tuberculosis using Mycobacterium tuberculosis-complex-specific antigens in a Tanzanian population with high prevalence of HIV. This study was performed to evaluate the usefulness, sensitivity and specificity of serology using M. tuberculosis-specific antigens in the diagnosis of tuberculosis in patients with and without HIV co-infection. Patients with proven pulmonary and extrapulmonary tuberculosis at a major referral centre in Tanzania were enrolled in the study. The control group consisted of patients without a history of previous tuberculosis admitted to the trauma ward and of healthy volunteers. Sera were analysed by an enzyme linked immunoassay (ELISA) using two M. tuberculosis specific proteins as antigen: the 38 kDa protein [3T] and a 17 kDa protein. In addition was recorded presence or absence of BCG scar and tuberculin sensitivity and the sera were tested for HIV and analysed for beta-2-microglobulin content. Sensitivity and specificity were markedly reduced in tuberculosis patients with HIV co-infection compared to patients without this disease (73% and 70% versus 52% and 50% respectively). Serology for diagnosis of tuberculosis is not feasible in an HIV endemic region.

References

Aug 1, 1992·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·L BarreraJ Castagnino
Oct 1, 1992·The Journal of Infectious Diseases·M Harboe, H G Wiker
Apr 1, 1991·The American Review of Respiratory Disease·B A Steele, T M Daniel
Jul 1, 1990·The Journal of Infectious Diseases·C M FarberJ P Van Vooren
May 1, 1989·The American Review of Respiratory Disease·R L ColebundersH L Francis
Jun 3, 1988·Science·J A Swets

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Citations

Aug 30, 2007·The Journal of Infectious Diseases·Mark D Perkins, Jane Cunningham
Jun 13, 2001·Infection and Immunity·K SamanichS Laal
Sep 11, 1999·Scandinavian Journal of Infectious Diseases·J CollazosJ Mayo
Jul 20, 2007·Scandinavian Journal of Immunology·F AbebeG Bjune
Jan 3, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Parasa V Ramana RaoAlamelu Raja
Jun 12, 2014·PloS One·Casey C PerleyRichard Frothingham
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Surya KantSavita Ahluwalia
Jul 7, 2000·Clinical and Diagnostic Laboratory Immunology·K M SamanichS Laal

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