Hunting for excitement: NMDA receptors in Huntington's disease

Neuron
Lisa M Ellerby

Abstract

Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, provide insight into the role of NMDA receptors in the cell-specific excitotoxic death observed in Huntington's disease (HD) using a HD mouse model expressing full-length mutant huntingtin (htt).

References

Feb 13, 2001·Molecular and Cellular Neurosciences·M M ZeronL A Raymond

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Citations

Dec 25, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rüdiger Hardeland
May 6, 2006·Behavioral and Brain Functions : BBF·V SrinivasanR Hardeland

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