Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors

Molecular and Cellular Biology
D S RaoT S Ross

Abstract

Huntingtin-interacting protein 1 (HIP1) interacts with huntingtin, the protein whose gene is mutated in Huntington's disease. In addition, a fusion between HIP1 and platelet-derived growth factor beta receptor causes chronic myelomonocytic leukemia. The HIP1 proteins, including HIP1 and HIP1-related (HIP1r), have an N-terminal polyphosphoinositide-interacting epsin N-terminal homology, domain, which is found in proteins involved in clathrin-mediated endocytosis. HIP1 and HIP1r also share a central leucine zipper and an actin binding TALIN homology domain. Here we show that HIP1, like HIP1r, colocalizes with clathrin coat components. We also show that HIP1 physically associates with clathrin and AP-2, the major components of the clathrin coat. To further understand the putative biological role(s) of HIP1, we have generated a targeted deletion of murine HIP1. HIP1(-/-) mice developed into adulthood, did not develop overt neurologic symptoms in the first year of life, and had normal peripheral blood counts. However, HIP1-deficient mice exhibited testicular degeneration with increased apoptosis of postmeiotic spermatids. Postmeiotic spermatids are the only cells of the seminiferous tubules that express HIP1. These findings indicate...Continue Reading

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Citations

May 6, 2005·Histochemistry and Cell Biology·Peter Redecker
Apr 3, 2004·Trends in Molecular Medicine·Teresa S Hyun, Theodora S Ross
Oct 18, 2002·Current Opinion in Cell Biology·Mark Stamnes
Jun 26, 2003·Bioorganic & Medicinal Chemistry Letters·Michael S SouthJohn J Parlow
Jul 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mingang XuNorman B Hecht
Jul 10, 2013·Molecular and Cellular Biology·Heather M AmesTheodora S Ross
Oct 16, 2003·Molecular and Cellular Biology·Anatoli B MeriinMichael Y Sherman
Aug 7, 2002·The Journal of Clinical Investigation·Dinesh S RaoTheodora S Ross
Jun 7, 2008·The Journal of Clinical Investigation·Renu N JainLinda C Samuelson
Jul 25, 2009·Cellular and Molecular Life Sciences : CMLS·Irit GottfriedUri Ashery
Jun 24, 2011·The Journal of Investigative Dermatology·Heather M AmesTheodora S Ross
Nov 27, 2007·Gene Expression Patterns : GEP·Pellegrino RossiRaffaele Geremia
Jun 11, 2004·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Tetsuya NakamotoHisamaru Hirai
Mar 28, 2008·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yoshie EndoYoichi Taya
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Feb 11, 2010·Genesis : the Journal of Genetics and Development·Yuta KomoikeToshiyuki Yamamoto
Jan 3, 2006·Journal of Reproductive Immunology·Simon WarbyFrancis Ouellette
Jul 14, 2012·Systems Biology in Reproductive Medicine·Jean-Louis DacheuxFrançoise Dacheux
Oct 22, 2016·PloS One·Sarita PanulaOuti Hovatta
Mar 5, 2004·Human Molecular Genetics·Katherine I Oravecz-WilsonTheodora S Ross
Sep 19, 2018·Molecular and Cellular Biology·Ranjula WijayatungeTheodora S Ross
Jan 16, 2010·Biochemical Society Transactions·Irit GottfriedUri Ashery
Jan 21, 2004·The Journal of Biological Chemistry·Teresa S HyunTheodora S Ross
Aug 26, 2020·Proceedings of the National Academy of Sciences of the United States of America·Hongbing JiangDavid Wang
Mar 25, 2017·Journal of Huntington's Disease·Jeh-Ping Liu, Scott O Zeitlin
Sep 19, 2007·Cancer Research·Sarah V BradleyTheodora S Ross
May 19, 2005·Cancer Research·Sarah V BradleyTheodora S Ross
Dec 29, 2020·Neuropathology and Applied Neurobiology·Conceição BettencourtJanice L Holton

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