PMID: 6167683Jan 1, 1981Paper

Huntington's chorea-- measurements of somatostatin, substance P and cyclic nucleotides in the cerebrospinal fluid

Journal of Neurology
H CramerE Schröter

Abstract

Somatostatin, substance P, cyclic AMP and cyclic GMP were determined in the cerebrospinal fluid of patients with Huntington's disease, in first generation relatives of choreic patients and in neurological control patients. Substance P levels were not significantly altered, but somatostatin levels were markedly decreased both in affected patients and symptom-free offspring. Cyclic AMP was decreased only in patients with advanced stages of the disease while cyclic GMP was normal. Evidence is discussed which may support a role of somatostatin deficiency in the pathophysiology of chorea.

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Citations

Jun 1, 1991·Journal of Neurology·A MolinsR Galard
Dec 1, 1984·Italian Journal of Neurological Sciences·A Albanese, M C Altavista
Nov 1, 1985·Journal of the Neurological Sciences·M F BealJ B Martin
Nov 8, 1982·Life Sciences·P L WoodN P Nair
Jan 1, 1984·Peptides·S M SagarJ B Martin
Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·D B Kee, J H Wood
Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·R H GernerP T Ninan
Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·D R RubinowJ C Ballenger
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·D R RubinowR M Post
Mar 1, 1993·The Japanese Journal of Psychiatry and Neurology·M YasudaK Maeda
Dec 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·R DursoT N Chase
Jan 1, 1982·Archiv für Psychiatrie und Nervenkrankheiten·J KohlerH Cramer
Jan 1, 1985·Annals of the New York Academy of Sciences·L J Thal
Mar 4, 2018·CNS Neuroscience & Therapeutics·Antonella Cardinale, Francesca R Fusco
Jul 1, 1982·Nature·S R VincentJ Kimmel
Dec 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·J JolkkonenP Riekkinen
Nov 13, 1986·The New England Journal of Medicine·J B Martin, J F Gusella
Oct 1, 1985·Journal of the American Geriatrics Society·O J ThienhausH B Bosmann
Apr 1, 1986·Biological Psychiatry·D R Rubinow
Nov 1, 1986·Annals of Neurology·M F Beal, J B Martin

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