Huntington's disease-like disorders in Latin America and the Caribbean

Parkinsonism & Related Disorders
Ruth H WalkerVitor Tumas

Abstract

Diseases with a choreic phenotype can be due to a variety of genetic etiologies. As testing for Huntington's disease (HD) becomes more available in previously resource-limited regions, it is becoming apparent that there are patients in these areas with other rare genetic conditions which cause an HD-like phenotype. Documentation of the presence of these conditions is important in order to provide appropriate diagnostic and clinical care for these populations. Information for this article was gathered in two ways; the literature was surveyed for publications reporting a variety of genetic choreic disorders, and movement disorders specialists from countries in Latin America and the Caribbean were contacted regarding their experiences with chorea of genetic etiology. Here we discuss the availability of molecular diagnostics for HD and for other choreic disorders, along with a summary of the published reports of affected subjects, and authors' personal experiences from the regions. While rare, patients affected by non-HD genetic choreas are evidently present in Latin America and the Caribbean. HD-like 2 is particularly prevalent in countries where the population has African ancestry. The incidence of other conditions is likely dete...Continue Reading

Citations

Oct 1, 2020·Practical Neurology·Daniel Sabino De OliveiraThiago Cardoso Vale
May 8, 2019·Movement Disorders Clinical Practice·David G AndersonAmanda Krause
Aug 25, 2020·Tremor and Other Hyperkinetic Movements·Daniel Martinez-RamirezUNKNOWN Rare Movement Disorders Study Group of International Parkinson’s Disease
Dec 26, 2018·Molecular Genetics & Genomic Medicine·Heinner GuioHugo Abarca-Barriga
Nov 27, 2020·Frontiers in Genetics·Carlos Alva-DiazMario Cornejo-Olivas

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