Huntington's disease: Neuropsychiatric manifestations of Huntington's disease

Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists
Anita My GohJeffrey Cl Looi

Abstract

Huntington's disease (HD) is a profoundly incapacitating, and ultimately fatal, neurodegenerative disease. HD is presently incurable, so the current goal is to allow affected individuals to live as well as possible with the illness, to maximise functional independence and quality of life for the person with HD, their carers and family members. This clinical update review focuses on the common neuropsychiatric manifestations in HD, and outlines and evaluates the various neuropsychiatric facets of HD, including the aetiology, symptoms and diagnosis. Neuropsychiatric symptoms can precede the classic motor clinical symptoms of HD (prodromal HD) by decades, and cause significant functional impairment. HD provides key insights and understanding into the organic psychiatric disorders, including contemporary clinical insights into the process of neurodegeneration and manifestation of neuropsychiatric symptoms.

References

Nov 17, 1983·Nature·J F GusellaA Y Sakaguchi
Aug 21, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·J S PaulsenJ L Cummings
Nov 17, 2006·Genetics in Medicine : Official Journal of the American College of Medical Genetics·M Kaye TrembathMartin B Delatycki
Jul 6, 2007·Journal of Psychiatric Research·Evangelos VassosDimitrios Vassilopoulos
Jul 1, 2008·The European Journal of Neuroscience·Joana M Gil, Ana Cristina Rego
Aug 24, 2011·Current Neurology and Neuroscience Reports·Jane S Paulsen
Jan 8, 2013·Genetic Testing and Molecular Biomarkers·Anita M Y GohUNKNOWN I-Respond-Hd Investigators Of The Huntington Study Group
Mar 13, 2013·JAMA Neurology·E Ray DorseyKevin M Biglan
May 6, 2014·Frontiers in Aging Neuroscience·Jane S PaulsenUNKNOWN PREDICT-HD Investigators and Coordinators of the Huntington Study Group
May 16, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Erik van DuijnUNKNOWN European Huntington's Disease Network Behavioural Phenotype Working Group
Jul 1, 2014·World Journal of Radiology·Flavia Niccolini, Marios Politis
Aug 29, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Ralf ReilmannChristopher A Ross
Oct 17, 2015·The American Journal of Psychiatry·Eric A EppingUNKNOWN PREDICT-HD Investigators and Coordinators of the Huntington Study Group
Jan 30, 2016·Neuroepidemiology·Michael D RawlinsLiam Smeeth
Nov 25, 2016·Neuroepidemiology·Germán Sánchez-DíazVerónica Alonso-Ferreira

❮ Previous
Next ❯

Citations

Aug 19, 2020·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Jeffrey Looi, Dennis Velakoulis
Aug 27, 2019·Frontiers in Neurology·Christopher J HeathBarbara J Sahakian
Jun 12, 2020·Neurobiology of Disease·Carolina GubertAnthony J Hannan
Aug 5, 2021·Orphanet Journal of Rare Diseases·Marie N N HellemJørgen E Nielsen
Aug 24, 2021·Frontiers in Cellular Neuroscience·Xiaoyu Dong, Shuyan Cong

❮ Previous
Next ❯

Methods Mentioned

BETA
contraception

Software Mentioned

COHORT
TRACK
PREDICT
Enroll
HD

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists
Samantha M LoiJeffrey Cl Looi
International Journal of Psychiatry in Medicine
M F Mendez
The Journal of the Royal College of Physicians of Edinburgh
C Turnbull, P Fitzsimmons
Movement Disorders : Official Journal of the Movement Disorder Society
Calum D MoultonW Richard Bevan-Jones
© 2022 Meta ULC. All rights reserved