Abstract
Huoxin Pill (HXP), a traditional Chinese medicine, has been prescribed widely in the treatment of coronary heart disease, angina pectoris, and other diseases. However, the possible protective mechanisms of HXP on myocardial ischemia remain unclear. In the current study, we investigated the effects and potential mechanism of HXP on myocardial ischemia and cardiac inflammation and the activation of TLR4/NF-κB pathway. Determination of electrocardiogram, echocardiography, and heart weight index (HWI) indicated that HXP treatment obviously attenuated the elevation of ST-segment, end-diastolic volume, and HWI in the AMI rat model. Enzyme-linked immunosorbent assay (ELISA) demonstrated that Huoxin Pill treatment significantly decreased the levels of CTnT, CK-MB, MDA, IL-6, and TNF-α, while it increased SOD content in serum of the AMI rat model. Moreover, hematoxylin and eosin (HE) and immunohistochemistry (IHC) staining revealed that HXP treatment alleviated pathological change, infiltration of inflammatory cells, levels of IL-6 and TNF-α, and expression of TLR4 and p-NF-κB in cardiac tissues of the AMI rat model. In conclusion, HXP treatment significantly improves cardiac function and attenuates cardiac inflammation by suppressing t...Continue Reading
References
May 12, 1998·Hypertension·A Y BagrovV M Shpen
Jan 25, 2005·Acta Pharmacologica Sinica·Yong ChengJun-Tian Zhang
Jul 18, 2006·Current Medicinal Chemistry·Nikolaos G Frangogiannis
Apr 17, 2007·The American Journal of Chinese Medicine·Andrew L RivardWalter C Low
May 19, 2009·European Journal of Pharmacology·Shou-bao WangGuan-hua Du
Sep 29, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Hiroyuki TsutsuiShouji Matsushima
Jan 10, 2012·Circulation Research·David J MarchantBruce M McManus
Dec 18, 2015·Circulation·UNKNOWN Writing Group MembersUNKNOWN Stroke Statistics Subcommittee
Jan 29, 2016·Life Sciences·Cengiz KocakIrfan Altuntas
Jun 11, 2016·International Immunopharmacology·Zhiheng HuangWeiwei Tao
Aug 10, 2016·PloS One·Vy LamJohn E Baker
Oct 1, 2016·Pharmaceutical Biology·Yan LiBin Yang
Oct 22, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kapil SuchalDharamvir Singh Arya
Feb 22, 2017·PloS One·Jing-Jing ZhangFu-Hai Ji
Mar 28, 2017·Journal of Ethnopharmacology·Chukwuemeka NwokochaRupika Delgoda
May 21, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xu ZhangJunguo Duan
Aug 19, 2017·Regional Anesthesia and Pain Medicine·Na WeiGuonian Wang
Aug 31, 2017·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Zengyong Qiao, Yawei Xu
Nov 18, 2017·Redox Biology·Qinhua JinHao Zhou
Dec 24, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yangang ChengMiaorong Pei
Feb 15, 2018·Frontiers in Pharmacology·Defang LiQiusheng Zheng
Aug 1, 2018·European Journal of Pharmacology·Libang YuanGu Gong
Feb 19, 2019·Lancet Neurology·UNKNOWN GBD 2016 Epilepsy Collaborators
Apr 30, 2019·Journal of Ethnopharmacology·Zhu LiChunquan Yu
May 23, 2019·Molecular Medicine Reports·Hai-Xiang XuQing-Jun Liu
May 28, 2019·Free Radical Research·Lin WuChangying Xing
Oct 12, 2019·Pharmacological Reports : PR·Negin AminiMohammad Badavi
Oct 19, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yanbin WangJunmin Wen
Oct 21, 2019·Journal of Molecular and Cellular Cardiology·Shan GaoGuanwei Fan
Nov 2, 2019·International Heart Journal·Liang LiuHuiliang Zhou
Nov 7, 2019·Personalized Medicine·Xiang-Dong YouJian-Jun Li
Nov 24, 2019·Neuroscience Letters·Jong Youl KimMidori A Yenari
Dec 21, 2019·Acta Cirúrgica Brasileira·Yejun BaiPeiying Zhang
Feb 1, 2020·Cellular and Molecular Life Sciences : CMLS·Bowei LiBo Hu
Feb 1, 2020·Pharmacological Reports : PR·Negin AminiMohammad Badavi