Huperzine A-phospholipid complex-loaded biodegradable thermosensitive polymer gel for controlled drug release

International Journal of Pharmaceutics
Xiaoqing CaiZhongxi Zhao

Abstract

The huperzine A-phospholipid complex loaded biodegradable thermosensitive PLGA-PEG-PLGA polymer gel was studied as injectable implant system for controlled release of huperzine-A (HA). First, HA molecules were successfully incorporated into the soybean phosphatidylcholine (SP) molecules to form the huperzine-A-soybean phosphatidylcholine complexes (HA-SPC), which was proved by FT-IR, DSC, XRD, solubility study, TEM, etc. The results indicated that hydrogen bonds and electrostatic interaction between HA and SP molecules play an important role in the formation of HA-SPC. Secondly, the HA-SPC was loaded into biodegradable PLGA-PEG-PLGA thermosensitive gel as injectable implant material to control the release of HA. The in vitro and in vivo drug release behaviors of the prepared products were studied. The in vitro release studies demonstrated that the HA-SPC-loaded gel significantly reduced the initial burst of drug release and extended the release period to about 2 weeks. The in vivo pharmacokinetics study of HA-SPC-loaded gel in rabbits showed that plasma concentration of HA (2.54-0.15ng/mL) was detected for nearly 2 weeks from delivery systems upon single subcutaneous injection. What's more, the in vitro release pattern correlat...Continue Reading

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Citations

Mar 26, 2013·International Journal of Pharmaceutics·Jifen ZhangNa Li
Oct 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yiqiong PuTong Zhang
Feb 16, 2019·Drug Development and Industrial Pharmacy·Sayan BiswasPritorthi Bhattacharjee
Feb 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Puxiu WangXing Tang
Mar 29, 2014·Soft Matter·Yiyun ChengTianfu Li
May 3, 2021·International Journal of Pharmaceutics·Passent M E GaafarOssama Y Abdallah

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