HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.

Gastroenterology
Mercedes Vázquez-ChantadaM Luz Martínez-Chantar

Abstract

Hepatic de-differentiation, liver development, and malignant transformation are processes in which the levels of hepatic S-adenosylmethionine are tightly regulated by 2 genes: methionine adenosyltransferase 1A (MAT1A) and methionine adenosyltransferase 2A (MAT2A). MAT1A is expressed in the adult liver, whereas MAT2A expression primarily is extrahepatic and is associated strongly with liver proliferation. The mechanisms that regulate these expression patterns are not completely understood. In silico analysis of the 3' untranslated region of MAT1A and MAT2A revealed putative binding sites for the RNA-binding proteins AU-rich RNA binding factor 1 (AUF1) and HuR, respectively. We investigated the posttranscriptional regulation of MAT1A and MAT2A by AUF1, HuR, and methyl-HuR in the aforementioned biological processes. During hepatic de-differentiation, the switch between MAT1A and MAT2A coincided with an increase in HuR and AUF1 expression. S-adenosylmethionine treatment altered this homeostasis by shifting the balance of AUF1 and methyl-HuR/HuR, which was identified as an inhibitor of MAT2A messenger RNA (mRNA) stability. We also observed a similar temporal distribution and a functional link between HuR, methyl-HuR, AUF1, and MAT1A...Continue Reading

References

Mar 1, 1988·Journal of Cellular Physiology·E G SchuetzP S Guzelian
Apr 1, 1995·Molecular and Cellular Biology·A M ZubiagaM E Greenberg
Apr 13, 2000·The International Journal of Biochemistry & Cell Biology·L TorreM A Avila
Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E R García-TrevijanoM A Avila
Apr 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·S C LuJ M Mato
Jun 28, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H YangS C Lu
Jan 5, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jose M MatoMatias A Avila
May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Covadonga PañedaIsabel Varela-Nieto
Jun 13, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria L Martínez-ChantarShelly C Lu
Apr 9, 2005·Genes and Immunity·J HuggettA Zumla
Sep 20, 2005·Molecular Cell·Vicky KatsanouDimitris L Kontoyiannis
Jul 13, 2006·Gastroenterology·María L Martínez-ChantarJosé M Mato
Jun 27, 2008·Cellular and Molecular Life Sciences : CMLS·M N Hinman, H Lou
Sep 17, 2008·Biochemical Society Transactions·Nuria Martínez-LópezMaria L Martinez-Chantar
Jan 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mercedes Vázquez-ChantadaJosé M Mato

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Citations

Oct 16, 2012·Nucleic Acids Research·Kotb AbdelmohsenMyriam Gorospe
Oct 18, 2012·Physiological Reviews·Shelly C Lu, José M Mato
Dec 18, 2012·The Journal of Clinical Investigation·Heping YangShelly C Lu
Aug 13, 2011·Thyroid Research·Bogusz TrojanowiczCuong Hoang-Vu
May 31, 2011·Frontiers in Bioscience (Landmark Edition)·Beth E Zucconi, Gerald M Wilson
Feb 26, 2014·International Journal of Molecular Sciences·Wenhui ZhaoDawei Guo
Feb 12, 2014·Journal of Cancer Research and Therapeutics·Na HanMengxian Zhang
Nov 12, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yingzhuo YangXia Wu
Oct 16, 2013·Antioxidants & Redox Signaling·Miguel DelgadoMaría Angeles Pajares
Nov 5, 2014·Nature Communications·Je-Hyun YoonMyriam Gorospe
Aug 13, 2014·Medical Oncology·Ioly Kotta-LoizouStamatios Theocharis
May 20, 2015·FEBS Letters·Nico SteinmeyerWolfgang Eberhardt
Jan 8, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tony GutschnerSven Diederichs
Feb 10, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maddalena FrauRosa M Pascale
Nov 19, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nieves EmbadeMaría L Martínez-Chantar
May 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ashwin WoodhooMaría L Martínez-Chantar
Jul 5, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Panagiota KafaslaDimitris L Kontoyiannis
Mar 8, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jens U Marquardt, Peter R Galle
Sep 4, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nuria Martínez-LópezMaria L Martínez-Chantar
Jun 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Frank ChenBenjamin L Shneider
Oct 18, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jin ZhangQuanyan Liu
Apr 2, 2014·Wiley Interdisciplinary Reviews. RNA·Ashleigh E MooreRobert J Schneider
Oct 5, 2014·Journal of Hepatology·Carmen Garcia-RuizJosé C Fernández-Checa
Aug 26, 2014·Virus Research·Shuo WuZhaohua Zhong
May 28, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Charlène VigourouxGuillaume Gauchotte
Aug 28, 2012·Biochemical and Biophysical Research Communications·Da-Quan SunDing-Gan Liu
Mar 24, 2011·Experimental Biology and Medicine·Marta Varela-ReyMaría L Martínez-Chantar
Dec 1, 2017·Antioxidants & Redox Signaling·María A Pajares, Dolores Pérez-Sala
Feb 5, 2014·The Journal of Pharmacology and Experimental Therapeutics·Elisa LatorreAlessandro Provenzani
Sep 26, 2019·Cancer Biology & Therapy·María Guadalupe Lozano-RosasVictoria Chagoya De Sánchez
Feb 25, 2020·The Biochemical Journal·Maicol ManciniEric Fabbrizio
Dec 2, 2010·Biochemical Society Transactions·Benoît LalooChristophe F Grosset
Feb 23, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yuan LiShelly C Lu
Jun 18, 2020·Nature Communications·Zhuojun ZhangWengong Wang
Sep 17, 2020·International Journal of Molecular Sciences·Dobrochna DolickaMichelangelo Foti

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