Hürthle cell carcinoma: a clinicopathological study of thirteen cases

Nuclear Medicine Communications
N Ozlem KüçükGülseren Aras

Abstract

Hürthle cell carcinoma (HCC) of the thyroid is a variant of follicular cancer which has been considered by many as a more aggressive disease than the usual well-differentiated carcinoma of the thyroid. To investigate the clinico-pathologic characteristics, treatment and outcome of Hürthle cell carcinoma. During a 7-year period, 13 patients (seven male, six female; mean age at diagnosis 48.4+/-13.2 years) with HCC were treated and monitored at the Ankara University. The measured diameter of the tumours varied from 1 to 6 cm in diameter with pathological examination. Three of the HCC had extra thyroid invasion, five had intrathyroid invasion, and five were encapsulated. One of the patients had a history of low-dose external radiation to the head and neck in childhood. Treatment consisted of a total thyroidectomy in 12 patients, and a near total thyroidectomy in one patient. At surgery, lymph node metastases were present in three patients and lymph node dissection were performed in these patients. Distant metastases were detected in only one patient (lung metastasis). All patients had radioiodine ablation therapy for residual thyroid tissue. Twelve of the 13 patients were ablated with a single dose of 131 I (3.7-5.5 GBq). A second...Continue Reading

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Citations

May 18, 2016·The Indian Journal of Surgery·Michael Shawky, Mahmoud Sakr
Dec 17, 2009·Histopathology·Oleksiy Tsybrovskyy, Martina Rössmann-Tsybrovskyy
Aug 24, 2021·Advances in Therapy·Andrés Coca-PelazAlfio Ferlito

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