Hürthle cell carcinoma of the thyroid: Retrospective review of 62 patients treated at the Royal Marsden Hospital between 1946 and 2003

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
S C MillsC L Harmer

Abstract

Previous studies have included Hürthle cell carcinoma (HCC) as a variant of follicular thyroid carcinoma in analysis of clinical outcome and others have failed to adequately distinguish between benign and malignant Hürthle cell neoplasms. The aim of this study was to report our experience of histologically confirmed malignant HCC, identifying patient, tumour and treatment factors that predict outcome. A retrospective review was undertaken of all patients treated with HCC between 1946 and 2003. Study end-points were disease-free survival (DFS) and cause-specific survival (CSS). Demographic, pathological and treatment-related factors were all correlated with the study end-points. Sixty-two patients were followed up for a median (range) of 58 months (2-629). On multivariate analysis, only extent of surgery (p<0.001) was an independent factor affecting CSS. Lymph node status (p=0.008), presence of metastases at diagnosis (p=0.005) and tumour stage (p=0.009) were independent predictors of DFS. HCC appears to be a separate entity from follicular thyroid carcinoma (FTC), with a more aggressive disease profile. Lymph node status, tumour stage, and the presence of metastases are independent predictors of DFS. Radical surgery may improve...Continue Reading

References

Oct 1, 1985·The Journal of Clinical Endocrinology and Metabolism·O H Clark, P L Gerend
Oct 1, 1993·American Journal of Surgery·S MasoodJ Attie
Nov 5, 1998·International Journal of Dermatology·S C BaekB K Cho
Mar 13, 2002·Annals of Surgical Oncology·Alexander StojadinovicAshok R Shaha
Feb 13, 2003·Archives of Otolaryngology--head & Neck Surgery·Neil Bhattacharyya
Feb 25, 2003·Cancer·Luis Lopez-PenabadSteven I Sherman
Jun 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Robert L FooteJan L Kasperbauer
May 11, 2004·European Journal of Endocrinology·Henry TaylorClive Harmer
Oct 1, 2004·World Journal of Surgery·Adolfo PisanuAlessandro Uccheddu
Oct 27, 2004·Advances in Anatomic Pathology·Virginia A LiVolsi, Zubair W Baloch
Feb 25, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I PaunovicM Havelka
Aug 8, 2006·Thyroid : Official Journal of the American Thyroid Association·Catharina Ihre Lundgren
Jan 1, 2011·BMJ Case Reports·Mark Anthony S Sandoval, Elizabeth Paz-Pacheco
Aug 16, 2012·Cancer·Paolo GoffredoJulie A Sosa

❮ Previous
Next ❯

Citations

Mar 23, 2012·Thyroid : Official Journal of the American Thyroid Association·Brendan C StackUNKNOWN American Thyroid Association Surgical Affairs Committee
Oct 12, 2010·The Journal of Clinical Endocrinology and Metabolism·Janete M CeruttiGregory J Riggins
Jul 21, 2015·Journal of Endocrinological Investigation·G DonatiniG Fromont
Mar 19, 2011·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·S KutunA Cetin
May 18, 2016·The Indian Journal of Surgery·Michael Shawky, Mahmoud Sakr
Sep 30, 2016·Radiology and Oncology·Andrej VogrinMaja Marolt Music
Aug 16, 2012·Cancer·Paolo GoffredoJulie A Sosa
Sep 27, 2014·The Journal of Clinical Endocrinology and Metabolism·Ana-Maria ChindrisRobert C Smallridge
Jul 20, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Vera WenterAndrei Todica
Aug 15, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Vera WenterAndrei Todica
Jun 11, 2021·Frontiers in Endocrinology·Sule CanberkValdemar Máximo
Jun 29, 2021·Frontiers in Endocrinology·Marcelo CorreiaManuel Sobrinho-Simões
Aug 24, 2021·Advances in Therapy·Andrés Coca-PelazAlfio Ferlito

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.