Hyaline-vascular castleman disease: a rare cause of solitary subcutaneous soft tissue mass

The American Journal of Dermatopathology
Mojdeh NaghashpourMarilyn M Bui

Abstract

Castleman disease (CD) is a rare lymphoproliferative disorder that primarily affects mediastinal, retroperitoneal, and cervical lymph nodes. Clinically, these lesions occur as a localized (unicentric) or less frequently as a systemic (multicentric) disease. Two main distinct histologic variants are recognized, the more common hyaline-vascular (HV) type and the plasma cell (PC) type. Extranodal Castleman disease, HV type (HVCD) is even less common. We describe a case of subcutaneous HVCD in a 57-year-old woman with a palpable chest mass and without systemic symptoms. Although the histologic findings are similar to those of HVCD in lymph nodes and other sites, a plethora of differential diagnosis is raised particularly with the more commonly occurring lymphoproliferative lesions in this location. This is one of the few bona fide cases of HVCD in subcutaneous location published to date. A review of the literature with an emphasis on pathogenesis of the disease subtypes is presented.

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Citations

Apr 30, 2011·Chinese Journal of Cancer·Yue-Min LiYong-Dong Pu
Aug 30, 2018·The Journal of Dermatology·Takuya HanamuraMasashi Akiyama
Jan 11, 2017·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·C PaaschM Strik

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Castleman Disease

Castleman disease is a rare disorder that involves an overgrowth of cells in the lymph nodes. Unicentric Castleman disease affects one lymph node, usually in the chest or abdomen. Multicentric Castleman disease affects multiple lymph nodes, commonly located in the neck, collarbone, underarm and groin areas. Discover the latest research on Castleman disease here.

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