Hyalinizing trabecular adenoma: A misnomer for a peculiar tumor of the thyroid gland

Endocrine Pathology
C SambadeM Sobrinho-Simões

Abstract

We describe the clinical, histological, immunohistochemical, and electron microscopical features of 9 tumors fulfilling the criteria of the so-called hyalinizing trabecular adenoma (HTA) of the thyroid. Six tumors had the characteristic histology of HTA throughout, whereas in the remaining 3 tumors the classic pattern was identified focally in otherwise typical or atypical follicular adenomas. In one case, there was a focus of tumoral tissue outside the capsule, and in another there was a regional lymph node metastasis. Seven tumors were immunoreactive for thyroglobulin and cytokeratins, 1 tumor was positive for thyroglobulin and negative for cytokeratins, and another was negative for thyroglobulin and positive for cytokeratins. Scattered cells immunoreactive for neurotensin and somatostatin were found in 2 cases. Every tumor stained for S100 protein and neuron-specific enolase, but none showed immunoreactivity for calcitonin, calcitonin gene-related peptide, or chromogranin. The irregularity of the nuclear contours, the prominence of the cytoplasmic bundles of intermediate filaments, and the accumulation of basal lamina material around the neoplastic cells without the interposition of a well-defined basal lamina were the most ...Continue Reading

References

Jun 1, 1990·Histopathology·J K ChanH S Chiu
Feb 1, 1986·American Journal of Clinical Pathology·M J VanstapelV D Desmet
Aug 1, 1987·The American Journal of Surgical Pathology·J A CarneyJ R Goellner
Jan 1, 1985·Ultrastructural Pathology·R HolmJ V Johannessen
Jan 1, 1986·Histopathology·L HjorthV T Nielsen

❮ Previous
Next ❯

Citations

Dec 16, 2000·The American Journal of Surgical Pathology·M PapottiG Chiappetta
Dec 16, 2000·The American Journal of Surgical Pathology·C C CheungS L Asa
Mar 27, 2003·The American Journal of Surgical Pathology·Robyn L GaffneyRicardo V Lloyd
Sep 25, 2008·The American Journal of Surgical Pathology·J Aidan CarneyThomas J Sebo
Jul 8, 2020·Endocrine Pathology·José Manuel Cameselle-TeijeiroManuel Sobrinho-Simões
Jul 1, 1997·The American Journal of Surgical Pathology·J LaGuetteJ Rosai
Nov 5, 1999·The Journal of Pathology·H R HarachD Bonneau
Sep 10, 2005·Expert Review of Molecular Diagnostics·Jennifer L Hunt
Mar 5, 2008·Histopathology·S GowrishankarJ A Carney
Mar 28, 2008·The American Journal of Surgical Pathology·J Aidan Carney
Aug 30, 2008·Endocrine Journal·Sang-Wook KangCheong Soo Park
Feb 24, 2000·The Annals of Otology, Rhinology, and Laryngology·P BoccatoA Ferlito
Oct 26, 2007·Endocrine Pathology·Vânia NoséMauro Papotti
Jan 17, 2019·Thyroid : Official Journal of the American Thyroid Association·Marina N NikiforovaYuri E Nikiforov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.