Hyalinizing trabecular adenoma of the thyroid. A report of two cases with cytologic, histologic and immunohistochemical findings

Acta Cytologica
Z Kaleem, R M Dávila

Abstract

Hyalinizing trabecular adenoma (HTA) is a rare benign thyroid tumor that is easily confused with medullary carcinoma on surgical specimens and with papillary carcinoma on cytologic specimens. The fine needle aspiration biopsies (FNABs) and surgically resected specimens from two patients with HTA were studied. Nuclear grooves and nuclear pseudoinclusions were identified in both FNABs. Gross examination of the surgical specimens revealed two nodules (0.8 and 0.5 cm in diameter) in one case and a 6-cm nodule in the other. A thin, fibrous capsule surrounded each nodule. A predominant trabecular pattern was observed in the three lesions. Antibodies to thyroglobulin, carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), vimentin, chromogranin, synaptophysin, neuron-specific enolase, proliferating cell nuclear antigen (PCNA), Ki-67 and p53 were used to stain 10% buffered, formalin-fixed, paraffin-embedded sections of the surgical specimens. No immunostaining was observed with antibodies against calcitonin, synaptophysin, chromogranin, EMA, vimentin or p53. Less than 5% of cells were CEA positive in one case. The Ki-67 index was low and PCNA expression high. HTAs occur as solitary or multiple nodules. FNABs of HTAs contain...Continue Reading

Citations

Jun 30, 2004·The American Journal of Surgical Pathology·Mary B CaseyJ Aidan Carney
Jan 13, 2006·Thyroid : Official Journal of the American Thyroid Association·Maximilian BockhornChristoph E Broelsch
Jul 7, 2007·Thyroid : Official Journal of the American Thyroid Association·Yukiko YanoKoichi Ito
Oct 26, 2007·Endocrine Pathology·Vânia NoséMauro Papotti
May 10, 2020·International Journal of Cancer. Journal International Du Cancer·Thais BasiliJorge S Reis-Filho
Feb 10, 1999·Diagnostic Cytopathology·M R Akin, G K Nguyen
Apr 11, 2000·The American Journal of Surgical Pathology·M Hirokawa, J A Carney
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Aug 21, 2004·Annals of Surgery·David J FinleyThomas J Fahey
Mar 4, 2020·Diagnostic Cytopathology·Yanjun HouDeborah J Chute
Jul 10, 2004·Thyroid : Official Journal of the American Thyroid Association·Maximilian BockhornChristoph E Broelsch

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