Hyalinizing trabecular adenoma of the thyroid gland: cytologic features in 29 cases

The American Journal of Surgical Pathology
Mary B CaseyJ A Carney

Abstract

Cytologic material (fine-needle aspiration biopsy smears, thin-layer preparations, cell block sections, and touch preparations) from 29 cases of hyalinizing trabecular adenoma was studied to 1) establish the cytologic profile of the neoplasm and 2) compare the profile with those of papillary and medullary carcinoma. Papanicolaou- and Diff-Quik-stained smears of the hyalinizing trabecular adenomas were uniformly bloody. The smears featured cells in cohesive aggregates radially oriented around hyaline material, less frequently, singly. Cytoplasm was abundant, and the nucleocytoplasmic ratio was low. Intranuclear cytoplasmic inclusions, nuclear grooves, and nuclear overlapping were very common and best seen with the Papanicolaou method. Diff-Quik-stained smears highlighted the hyaline material (metachromatic), perinucleolar clearing, and cytoplasmic bodies. The combination of a bloody background, radially oriented cohesive cells, cells with abundant cytoplasm, nuclei with very frequent cytoplasmic inclusions and grooves, and the presence of hyalin should suggest the presence of hyalinizing trabecular adenoma.

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Citations

Oct 26, 2007·Endocrine Pathology·Vânia NoséMauro Papotti
Jul 2, 2011·Head and Neck Pathology·P CaraciS Aversa
Mar 28, 2008·The American Journal of Surgical Pathology·J Aidan Carney
Sep 25, 2008·The American Journal of Surgical Pathology·J Aidan CarneyThomas J Sebo
Apr 27, 2013·Histopathology·Daniela LenggenhagerMatthias Rössle
Aug 24, 2010·Diagnostic Cytopathology·Justin A Bishop, Syed Z Ali
Jul 18, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·A RyskaA Kohout
Oct 22, 2009·Cytopathology : Official Journal of the British Society for Clinical Cytology·S AgarwalP Sinha
Sep 10, 2005·Expert Review of Molecular Diagnostics·Jennifer L Hunt
May 7, 2011·Diagnostic Cytopathology·Sandeep Kumar Arora, Pranab Dey
Jul 8, 2011·Cytopathology : Official Journal of the British Society for Clinical Cytology·T KimJ H Shin
Jan 17, 2019·Thyroid : Official Journal of the American Thyroid Association·Marina N NikiforovaYuri E Nikiforov
Oct 2, 2019·Head and Neck Pathology·Esther Diana RossiLiron Pantanowitz
Sep 13, 2012·Experimental and Therapeutic Medicine·Jing LiLin Li
Oct 30, 2014·Diagnostic Cytopathology·Elwira Bakuła-ZalewskaHenryk A Domanski
Mar 20, 2010·Cytopathology : Official Journal of the British Society for Clinical Cytology·S AgarwalP Sinha
Aug 14, 2021·Annals of Diagnostic Pathology·Peter Podany, Syed M Gilani

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