Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44

The Journal of Clinical Investigation
C M McKeeP W Noble

Abstract

Hyaluronan (HA) is a glycosaminoglycan constituent of extracellular matrix. In its native form HA exists as a high molecular weight polymer, but during inflammation lower molecular weight fragments accumulate. We have identified a collection of inflammatory genes induced in macrophages by HA fragments but not by high molecular weight HA. These include several members of the chemokine gene family: macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, cytokine responsive gene-2, monocyte chemoattractant protein-1, and regulated on activation, normal T cell expressed and secreted. HA fragments as small as hexamers are capable of inducing expression of these genes in a mouse alveolar macrophage cell line, and monoclonal antibody to the HA receptor CD44 completely blocks binding of fluorescein-labeled HA to these cells and significantly inhibits HA-induced gene expression. We also investigated the ability of HA fragments to induce chemokine gene expression in human alveolar macrophages from patients with idiopathic pulmonary fibrosis and found that interleukin-8 mRNA is markedly induced. These data support the hypothesis that HA fragments generated during inflammation induce the expression of macrophage gene...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Nov 1, 1975·Carbohydrate Research·A N de Belder, K O Wik
Dec 11, 1992·Science·A E KochR M Strieter
Jun 1, 1992·The Journal of Cell Biology·C HardwickE A Turley
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A D YurochkoS Haskill
Sep 1, 1992·The Journal of Clinical Investigation·A E KochR M Strieter
Jun 1, 1992·The American Review of Respiratory Disease·J P LynchR M Strieter
Jun 1, 1991·Annals of the Rheumatic Diseases·H Saari
Jan 1, 1991·Immunologic Research·S MurakamiR J Hodes
Feb 1, 1990·The Journal of Experimental Medicine·K MiyakeP W Kincade
Mar 1, 1989·The American Review of Respiratory Disease·O NettelbladtR Hällgren
Nov 1, 1988·The Journal of Clinical Investigation·W N RomR G Crysal
Nov 1, 1985·Annals of the Rheumatic Diseases·J D McNeilL G Cleland
Jun 29, 1984·Biochemical and Biophysical Research Communications·E Turley, D Moore
Aug 1, 1980·International Journal of Cancer. Journal International Du Cancer·S TsuchiyaK Tada
Mar 1, 1994·Cancer Research·M B PennoC Rosada
Jul 1, 1994·The Journal of Experimental Medicine·A BartolazziI Stamenkovic
Feb 1, 1995·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·O OksalaH Larjava
Mar 1, 1995·The Journal of Clinical Investigation·R C SavaniE A Turley
Jul 1, 1995·The Journal of Experimental Medicine·A L AngiolilloG Tosato
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·E PapakonstantinouL H Block
Apr 15, 1994·Transplantation·L E WrenshallJ L Platt
Dec 1, 1993·Glycoconjugate Journal·K KuboM Endo
Sep 1, 1993·Thorax·J GauldieG Cox
Jan 1, 1994·American Journal of Respiratory Cell and Molecular Biology·D L LaskinD J Riley
Jan 1, 1994·Annals of the Rheumatic Diseases·G YanniB Bresnihan
Feb 1, 1993·The Journal of Cell Biology·R L Juliano, S Haskill
Feb 1, 1993·Developmental Biology·C B UnderhillM Culty
Jul 14, 2004·Critical Reviews in Eukaryotic Gene Expression·Xueli Fan, Jason J Chen

❮ Previous
Next ❯

Citations

Jun 30, 1998·International Journal of Cancer. Journal International Du Cancer·R T PirinenV M Kosma
May 16, 2001·Arthritis and Rheumatism·G H YuanK Nishioka
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D C RockeyP W Noble
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·B MytarM Zembala
Jul 13, 2002·Journal of Biomedical Materials Research·Toshihiro HabaraTakafumi Kudo
Jul 31, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Glenda ErnstSilvia E Hajos
Jan 25, 2011·Annals of Hematology·Magdalena Katharina HertweckKarl-Anton Kreuzer
Dec 8, 2004·Rheumatology International·Michiaki TanakaHiroshi Nakamura
Feb 3, 2011·Lung·Lina María Salazar, Ana Milena Herrera
Jun 27, 2013·Current Pain and Headache Reports·Antonio SteccoRobert Stern
Apr 28, 2004·Cytokine & Growth Factor Reviews·Hans-Georg Wisniewski, Jan Vilcek
Jun 23, 1999·Experimental Hematology·S GhaffariC Eaves
Dec 4, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·G N CherrJ W Overstreet
Feb 6, 2002·Matrix Biology : Journal of the International Society for Matrix Biology·Paul W Noble
Oct 23, 1997·Current Opinion in Cell Biology·P W KincadeL Hanson
Aug 19, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·D S ZanderJ K Massey
Oct 29, 2003·Pulmonary Pharmacology & Therapeutics·Mario Scuri, William M Abraham
Mar 26, 2003·Microbes and Infection·Wendy Peters, Joel D Ernst
Jun 24, 1999·Cytokine & Growth Factor Reviews·E Van CoillieG Opdenakker
May 30, 2001·Trends in Immunology·D G JacksonS Banerji
Mar 5, 2003·Trends in Immunology·Christian TermeerJan C Simon
Apr 28, 2001·Trends in Molecular Medicine·E Puré, C A Cuff
Jun 26, 2001·Trends in Parasitology·J G BeesonG V Brown
Sep 22, 2009·The Journal of Organic Chemistry·Xiaowei LuXuefei Huang
Jan 9, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Chien-Hsi ChenPatrick C H Hsieh
Sep 25, 2010·Nature Reviews. Immunology·Lydia Sorokin
Aug 9, 2006·Cell Research·Dianhua JiangPaul W Noble
Feb 24, 2001·Respirology : Official Journal of the Asian Pacific Society of Respirology·H IshiiM Yoshida
Apr 23, 2002·Kidney International·Marjorie E Dunlop, Evelyne E Muggli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.