Hyaluronan in the interphotoreceptor matrix of the eye: species differences in content, distribution, ligand binding and degradation

Experimental Eye Research
J G HollyfieldR Tammi

Abstract

Hyaluronan (HA) distribution in the posterior eye wall from the vitreous through the sclera, with special consideration to localization in the retina and interphotoreceptor matrix (IPM), was evaluated in human, bovine, guinea pig, dog, rat and mouse tissues using a specific probe for HA (bHABC, biotinylated hyaluronan binding complex). The sclera, some regions of the choroid and vitreous body was positive for HA, as was the basal lamina of the retina (inner limiting membrane). bHABC binding was detected in the IPM of all species studied except the mouse. Predigestion with Streptomyces hyaluronidase for 3 hr before bHABC application eliminated binding in the vitreous, choroid, sclera and basal lamina of the retina, but did not eliminate bHABC binding in the IPM. In tissues from all species studied, incubation for 6 hr with hyaluronidase eliminated bHABC binding in the IPM, except for two human samples. In these two human samples, HA specific binding in the IPM persisted even after 24 hr enzyme treatment. bHABC failed to bind to any tissue layer when bHABC was preincubated with hyaluronan oligosaccharides before application. The resistance of the IPM HA to hyaluronidase digestion may reflect extensive coverage of HA binding sites...Continue Reading

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Citations

Sep 23, 2008·The Journal of Biological Chemistry·S Patricia BecerraJoe G Hollyfield
Aug 27, 2005·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Masatoshi Murata, Saburo Horiuchi
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