Hyaluronan-mediated motility receptor expression functions as a prognostic biomarker in uterine carcinosarcoma based on bioinformatics analysis.

The Journal of International Medical Research
Hui SunJie Chen

Abstract

Uterine carcinosarcoma (UCS) is a rare, aggressive tumour with a high metastasis rate and poor prognosis. This study aimed to explore potential key genes associated with the prognosis of UCS. Transcriptional expression data were downloaded from the Gene Expression Profiling Interactive Analysis database and differentially expressed genes (DEGs) were subjected to Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses using Metascape. A protein-protein interaction network was constructed using the STRING website and Cytoscape software, and the top 30 genes obtained through the Maximal Clique Centrality algorithm were selected as hub genes. These hub genes were validated by clinicopathological and sequencing data for 56 patients with UCS from The Cancer Genome Atlas database. A total of 1894 DEGs were identified, and the top 30 genes were considered as hub genes. Hyaluronan-mediated motility receptor (HMMR) expression was significantly higher in UCS tissues compared with normal tissues, and elevated expression of HMMR was identified as an independent prognostic factor for shorter survival in patients with UCS. These results suggest that HMMR may be a potential biomarker for predicting the prognosis of patients with UCS.

References

Jan 15, 2003·BMC Bioinformatics·Gary D Bader, Christopher W V Hogue
Jan 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Avril V SomlyoAndrew P Somlyo
Mar 21, 2008·Journal of Cell Science·Christopher Alan MaxwellEva Turley
Jun 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Inti ZlobecAlessandro Lugli
Feb 10, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·K GalaalR J Edmondson
Sep 3, 2009·Neoplasia : an International Journal for Oncology Research·Kilian M GustMark Ringhoffer
Apr 7, 2010·Obstetrics and Gynecology International·Norasate SamarnthaiI-Tien Yeh
Mar 26, 2011·BMC Cancer·Sumiya IshigamiShoji Natsugoe
Jul 12, 2011·Current Opinion in Oncology·Rebecca ArendJason D Wright
Oct 19, 2011·Obstetrics and Gynecology International·Rani Kanthan, Jenna-Lynn Senger
Jul 25, 2014·PLoS Computational Biology·Rekin's JankyStein Aerts
Oct 30, 2014·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Dec 4, 2014·Critical Reviews in Oncology/hematology·Grazia ArtioliFranco Garbin
Dec 19, 2014·BMC Systems Biology·Chia-Hao ChinChung-Yen Lin
Dec 8, 2015·Geburtshilfe und Frauenheilkunde·D DenschlagM W Beckmann
Apr 8, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K MatsuoL D Roman
Jan 16, 2017·Neoplasia : an International Journal for Oncology Research·Jing LiTing Wang
Apr 5, 2019·Nature Communications·Yingyao ZhouSumit K Chanda

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Software Mentioned

Molecular Complex Detection ( MCODE )
SPSS
cBioPortal
Prism7
Gene Expression Profiling Interactive Analysis
STRING
Cytoscape
Search Tool for the Retrieval of
cytoHubba
Cytoscape iRegulon

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