PMID: 11336799May 5, 2001Paper

Hyaluronan reduces migration and proliferation in CHO cells

Biochimica Et Biophysica Acta
B DübeP Prehm

Abstract

Expression of the hyaluronan synthase gene in hyaluronan-deficient CHO cells changed the cell morphology from a spindle shape to a flattened epithelial-type form. Hyaluronan producing CHO cells showed reduced initial cell adhesion, migration, proliferation and density at contact inhibition, but no difference in random migration determined by the Boyden chamber assay. Addition of hyaluronan to the medium of CHO cells reduced migration, proliferation and initial cell adhesion. In contrast, coating the plastic dish with hyaluronan enhanced initial cell adhesion. These results are discussed in the context of the perplexing properties of hyaluronan on cellular functions.

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Citations

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Feb 9, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Prabhpreet K DhillonBingyun Sun
Jan 25, 2019·Cell Adhesion & Migration·Zeinab Al-RekabiNathan J Sniadecki
Aug 20, 2005·Journal of Cellular Physiology·Thomas S WilkinsonThomas N Wight
Feb 11, 2014·The Journal of Biological Chemistry·Ashik Jawahar DeenMarkku I Tammi
May 16, 2007·The Journal of Biological Chemistry·Alamelu G BharadwajMelanie A Simpson

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