PMID: 15375493Sep 18, 2004Paper

Hyaluronan synthase expression in ovarian cancer

Oncology Reports
Hiromitsu YabushitaMasayoshi Noguchi

Abstract

To determine if the immunohistochemical expression of hyaluronan synthase (HAS) correlates with the clinicopathological manifestations or clinical outcomes of ovarian carcinoma, sections of tumor tissue from 33 ovarian cancer patients were immunostained by the avidin-biotin-peroxidase complex method using anti-HAS1, anti-HAS2, anti-HAS3 and anti-CD44 antibody. A section was defined as having positive expression when >50% of the tumor cells were intensely stained. The microvessel density, which was defined as the mean number of new vessels, was determined under light microscopy. In the 33 ovarian cancer cases, 12 cases had positive expression of HAS1, 21 cases had positive expression of HAS2 and 11 cases had positive expression of HAS3. The expression of HAS1, HAS2 and HAS3 was unrelated to the stage of disease. CD44 expression occurred more frequently in the HAS1-positive group than in the HAS1-negative group, but the expression of HAS2 and HAS3 was unrelated to CD44 expression. The microvessel density was higher in the HAS1-positive group than in the HAS1-negative group. But the microvessel density did not differ in relation to the expression of HAS2 and HAS3. In the 23 patients that received chemotherapy, the expression of HA...Continue Reading

Citations

Jun 25, 2014·Clinical & Experimental Metastasis·Kunihiro IkutaYoshihiro Nishida
Oct 18, 2014·Cancer Metastasis Reviews·Anja SchmausJonathan P Sleeman
Jun 23, 2006·Breast Cancer Research and Treatment·María D CorteFrancisco J Vizoso
Dec 13, 2006·Wiener medizinische Wochenschrift·Karl M Stuhlmeier
Jan 1, 2013·Medical Oncology·Hatem A El-MezayenFatheya M Metwally
Nov 19, 2015·Frontiers in Oncology·Angela ChoEmily K Colvin
Jan 19, 2007·International Journal of Cancer. Journal International Du Cancer·Roozbeh GolshaniVinata B Lokeshwar
Aug 9, 2005·Pathologie-biologie·Robert Stern
May 3, 2008·Seminars in Cancer Biology·Naoki Itano, Koji Kimata
Feb 24, 2015·Frontiers in Immunology·Hanna SiiskonenKirsi Rilla
Apr 12, 2019·The FEBS Journal·Alberto PassiRenato V Iozzo
Oct 18, 2016·Pancreas·Shiro KohiKeiji Hirata
Aug 25, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Li ChenQuan Wei

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