Hyaluronate improves pain, physical function and balance in the geriatric osteoarthritic knee: a 6-month follow-up study using clinical tests

Osteoarthritis and Cartilage
Shu-Fen SunYu-Ling Wang

Abstract

To investigate the effects of intraarticular hyaluronic acid (HA) (Artzal, Seikagaku Corp., Japan) in geriatric participants with unilateral knee osteoarthritis (OA). This was a prospective, observer-blind study with 6 months follow-up done in the setting of an outpatient rehabilitation department in a university-affiliated tertiary care medical center. Sixty-eight patients, aged 65 years or above, with symptoms and radiographic evidence of unilateral knee OA for at least 6 months were recruited. Patients received five weekly intraarticular injections of Artzal into symptomatic knees. Fifty-six participants completed the study. Fifty age-, body mass- and gender-matched healthy individuals were selected as control. Visual analog scale (VAS), Lequesne index and four balance tests including single-leg stance test (SLS), function reach test (FRT), timed "Up-and-Go" test (TUG) and Berg balance scale (BBS) were assessed before injection and at each follow-up visit in the OA group. Four balance tests were obtained on healthy participants for data comparison. Before Artzal injections, the OA group showed significantly worse VAS, Lequesne index and four balance tests scores than did the control group (P < 0.001). Significant improvement...Continue Reading

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Citations

Feb 19, 2013·PM & R : the Journal of Injury, Function, and Rehabilitation·Heather K VincentKevin R Vincent
Apr 19, 2013·Revista española de cirugía ortopédica y traumatología·A Borrás-VerderaC Clavel-Sainz
May 17, 2011·Journal of the American Geriatrics Society·Joseph DecariaManuel Montero-Odasso
Apr 17, 2012·Annals of Rehabilitation Medicine·Ki Young OhYoung Seop Lee
Dec 7, 2017·American Journal of Physical Medicine & Rehabilitation·Yung-Tsan WuLiang-Cheng Chen
Jun 1, 2018·Journal of Managed Care & Specialty Pharmacy·Jack BertMaria Lopes
Nov 28, 2013·Journal of Exercise Rehabilitation·Bo-Ae LeeDeuk-Ja Oh
Apr 26, 2019·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Amy BronstoneVinod Dasa

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