Hyaluronate/lactoferrin layer-by-layer-coated lipid nanocarriers for targeted co-delivery of rapamycin and berberine to lung carcinoma

Colloids and Surfaces. B, Biointerfaces
Dalia M KabaryAhmed O Elzoghby

Abstract

The self-tumor targeting polymers, lactoferrin (LF) and hyaluronic acid (HA) were utilized to develop layer-by-layer (LbL) lipid nanoparticles (NPs) for dual delivery of berberine (BER) and rapamycin (RAP) to lung cancer. To control its release from the NPs, BER was hydrophobically ion paired with SLS prior to incorporation into NPs. Spherical HA/LF-LbL-RAP-BER/SLS-NPs 250.5 nm in diameter, with a surface charge of -18.5 mV were successfully elaborated. The NPs exhibited sequential release pattern with faster release of BER followed by controlled release of RAP which enables sensitization of lung tumor cells to the anti-cancer action of RAP. LbL coating of the NPs was found to enhance the drug cytotoxicity against A549 lung cancer cells as augmented by remarkable increase in their cellular internalization through CD44 receptors overexpressed by tumor cells. In vivo studies in lung cancer bearing mice have revealed the superior therapeutic activity of LbL-RAP-BER/SLS-NPs over the free drugs as demonstrated by 88.09% reduction in the average number of microscopic lung foci and 3.1-fold reduction of the angiogenic factor VEGF level compared to positive control. Overall, the developed HA/LF-LbL-coated lipid NPs could be potential c...Continue Reading

Citations

Jan 31, 2020·Expert Opinion on Drug Delivery·Dina A HafezAhmed O Elzoghby
Aug 22, 2020·Expert Opinion on Drug Delivery·Islam A Hassanin, Ahmed O Elzoghby
Aug 8, 2019·Expert Opinion on Drug Delivery·Yu Sakurai, Hideyoshi Harashima
Nov 20, 2020·International Journal of Biological Macromolecules·Mona M Agwa, Sally Sabra
Jun 17, 2020·Colloids and Surfaces. B, Biointerfaces·Hossein MajidzadehMichael R Hamblin
Feb 10, 2021·Phytotherapy Research : PTR·Nalini DevarajanSenthil Kumar Ganesan
Aug 21, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kholod A ElhasanyAhmed O Elzoghby
May 6, 2021·Nanoscale·Akmal M AsrorovYongzhuo Huang
May 25, 2021·Journal of Biomaterials Science. Polymer Edition·Honglei GuoXiangchun Shen
May 26, 2021·Expert Opinion on Drug Delivery·Eder Lilia Romero, Maria Jose Morilla
Nov 1, 2020·International Journal of Pharmaceutics·Gulin AmasyaCatherine Amiel
Jul 14, 2021·Expert Opinion on Drug Delivery·Doaa M AnwarAhmed O Elzoghby
Jul 4, 2019·ACS Applied Materials & Interfaces·Mona A AbdelmoneemAhmed O Elzoghby
Dec 16, 2020·ACS Biomaterials Science & Engineering·Marian G RofealSanaa Omar
Jan 20, 2021·ACS Biomaterials Science & Engineering·Hadeer M AbdelazizMay S Freag
Aug 31, 2021·Frontiers in Pharmacology·Zhibang HuangShaofen Xu

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