Hyaluronic acid, an efficient biomacromolecule for treatment of inflammatory skin and joint diseases: A review of recent developments and critical appraisal of preclinical and clinical investigations

International Journal of Biological Macromolecules
Li Hui ChenZahid Hussain

Abstract

Hyaluronic acid (HA) plays multifaceted role in regulating various biological processes and maintaining homeostasis into the body. Numerous researches evidenced the biomedical implications of HA in skin repairmen, cancer prognosis, wound healing, tissue regeneration, anti-inflammatory, immunomodulation. The present review was aimed to summarize and critically appraise the recent developments and efficacy of HA for treatment of inflammatory skin and joint diseases. A thorough analysis of the literature revealed that HA based formulations (i.e., gels, creams, autologous graft, thin sheets, soaked gauze, gauze pad, tincture, injection) have shown remarkable efficacy in treating a wide range of inflammatory skin diseases. The safety, tolerability, and efficacy of HA (as intra-articular injection) have also been well-documented for treatment of various types of joint disease including knee osteoarthritic, joint osteoarthritis, canine osteoarthritis, and meniscal swelling. Intra-articular injection of HA produces remarkable reduction in joint pain, synovial inflammation, and articular swelling. A remarkable improvement in chondrocyte density, territorial matrix appearance, reconstitution of superficial amorphous layer of the cartilag...Continue Reading

Citations

Jun 20, 2019·Expert Opinion on Drug Delivery·Barbara ViganiFranca Ferrari
Jul 25, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Xinbo WuTerence T Lao
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Jan 22, 2021·International Journal of Biological Macromolecules·Karine Cappuccio CastroLucia Helena Innocentini Mei
Oct 15, 2020·Advanced Healthcare Materials·Eloïse LebaudyVarvara Gribova
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Sep 21, 2021·Clinical Oral Investigations·Sadeq Ali Al-MaweriEsam Halboub
Sep 28, 2021·Current Eye Research·Christina JacobiThomas Kärcher

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