Abstract
Hyaluronic acid (HA) plays multifaceted role in regulating various biological processes and maintaining homeostasis into the body. Numerous researches evidenced the biomedical implications of HA in skin repairmen, cancer prognosis, wound healing, tissue regeneration, anti-inflammatory, immunomodulation. The present review was aimed to summarize and critically appraise the recent developments and efficacy of HA for treatment of inflammatory skin and joint diseases. A thorough analysis of the literature revealed that HA based formulations (i.e., gels, creams, autologous graft, thin sheets, soaked gauze, gauze pad, tincture, injection) have shown remarkable efficacy in treating a wide range of inflammatory skin diseases. The safety, tolerability, and efficacy of HA (as intra-articular injection) have also been well-documented for treatment of various types of joint disease including knee osteoarthritic, joint osteoarthritis, canine osteoarthritis, and meniscal swelling. Intra-articular injection of HA produces remarkable reduction in joint pain, synovial inflammation, and articular swelling. A remarkable improvement in chondrocyte density, territorial matrix appearance, reconstitution of superficial amorphous layer of the cartilag...Continue Reading
Citations
Jun 20, 2019·Expert Opinion on Drug Delivery·Barbara ViganiFranca Ferrari
Jul 25, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Xinbo WuTerence T Lao
Jul 25, 2019·Journal of Drug Targeting·Marialucia GalloriniLeonardo Osti
Apr 7, 2019·The British Journal of Dermatology·K LiuS Zhou
Aug 2, 2019·Current Pharmaceutical Design·Mohammed A S Abourehab, Zahid Hussain
Dec 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eunju ChoiJae Youl Cho
Aug 14, 2020·Nanoscale·Lei YangYuanjin Zhao
Feb 7, 2019·Food & Function·Runhua LiuXuebo Liu
Mar 22, 2019·Drug Delivery and Translational Research·Zahid HussainMarcel de Matas
May 28, 2020·Frontiers in Pharmacology·Mingying DengAizong Shen
Oct 24, 2020·Cartilage·Michael J LangworthyDavid Webner
Jan 15, 2021·Acta Biomaterialia·Binhong TengShicheng Wei
Jan 22, 2021·International Journal of Biological Macromolecules·Karine Cappuccio CastroLucia Helena Innocentini Mei
Oct 15, 2020·Advanced Healthcare Materials·Eloïse LebaudyVarvara Gribova
Mar 13, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Marisa AssunçãoAnna Blocki
Oct 12, 2020·International Journal of Biological Macromolecules·Chenxi LiYuanyan Liu
May 15, 2021·Advanced Materials·Yongsheng GaoSamir Mitragotri
Sep 21, 2021·Clinical Oral Investigations·Sadeq Ali Al-MaweriEsam Halboub
Sep 28, 2021·Current Eye Research·Christina JacobiThomas Kärcher