Hyaluronic Acid and Controlled Release: A Review.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Ilker S Bayer

Abstract

Hyaluronic acid (HA) also known as hyaluronan, is a natural polysaccharide-an anionic, non-sulfated glycosaminoglycan-commonly found in our bodies. It occurs in the highest concentrations in the eyes and joints. Today HA is used during certain eye surgeries and in the treatment of dry eye disease. It is a remarkable natural lubricant that can be injected into the knee for patients with knee osteoarthritis. HA has also excellent gelling properties due to its capability to bind water very quickly. As such, it is one the most attractive controlled drug release matrices and as such, it is frequently used in various biomedical applications. Due to its reactivity, HA can be cross-linked or conjugated with assorted bio-macromolecules and it can effectively encapsulate several different types of drugs, even at nanoscale. Moreover, the physiological significance of the interactions between HA and its main membrane receptor, CD44 (a cell-surface glycoprotein that modulates cell-cell interactions, cell adhesion and migration), in pathological processes, e.g. cancer, is well recognized and this has resulted in an extensive amount of studies on cancer drug delivery and tumor targeting. HA acts as a therapeutic but also as a tunable matrix f...Continue Reading

References

Nov 14, 1997·Journal of Biomedical Materials Research·K Tomihata, Y Ikada
Oct 6, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y LuoG D Prestwich
Nov 17, 2001·Biomacromolecules·Y LuoG D Prestwich
Apr 12, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mee Ryang Kim, Tae Gwan Park
Nov 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elizabeth L HedbergAntonios G Mikos
Jun 16, 2005·Bioorganic & Medicinal Chemistry·Stanislav JaraczIwao Ojima
Jul 27, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Harold J Brody
Mar 16, 2006·The British Journal of Dermatology·M GhislanzoniE Alessi
Oct 3, 2006·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hiroaki MatsunoSyogo Kano
Oct 31, 2006·Journal of Biomedical Materials Research. Part a·Sei Kwang HahnTsuyoshi Shimobouji
Nov 4, 2006·Advanced Drug Delivery Reviews·Chien-Chi Lin, Andrew T Metters
Apr 6, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyukjin LeeTae Gwan Park
Sep 13, 2008·Journal of Colloid and Interface Science·Xiaoqiang CuiZhisong Lu
Jan 6, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fan LeeMotoichi Kurisawa
Mar 28, 2009·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Matteo FagnolaAntonio Papagni
Sep 18, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eun Ju OhSei Kwang Hahn
Feb 15, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elena Martínez-SanzOommen P Varghese
Apr 26, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Glenn D Prestwich
Aug 4, 2011·The Journal of Antibiotics·Ping GaoGang Cheng
May 19, 2012·Macromolecular Bioscience·Takashi NakaiKazunari Akiyoshi
Nov 20, 2012·Biomacromolecules·Yanina MinaberryMatías Jobbágy
Apr 17, 2013·International Journal of Pharmaceutics·Giovanna PitarresiGaetano Giammona
Oct 17, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ming ChenSamir Mitragotri
Nov 28, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ju-Hwan ParkDae-Duk Kim
Mar 20, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·E MontanariP Matricardi
Mar 25, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Ana-Maria VasiLiliana Verestiuc
Jul 6, 2014·Colloids and Surfaces. B, Biointerfaces·Ju-Hwan ParkDae-Duk Kim
Jul 20, 2014·Carbohydrate Polymers·Gloria Huerta-AngelesVladimír Velebný
Aug 2, 2014·Advances in Cancer Research·Vinata B LokeshwarAndre Jordan
Sep 25, 2014·Expert Opinion on Drug Delivery·Ravi VaishyaAshim K Mitra

❮ Previous
Next ❯

Citations

Aug 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Javad TavakoliYouhong Tang
Jan 1, 2021·International Journal of Biological Macromolecules·Belen Reig-VanoMarta Giamberini
Mar 7, 2021·International Journal of Molecular Sciences·Lenka MusilováAna C F Ribeiro
Apr 30, 2021·Carbohydrate Polymers·Xiaodan ZhangQiang Zhu
May 10, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Jon Andrade Del OlmoLeyre Pérez-Álvarez
Jun 3, 2021·International Journal of Molecular Sciences·Evgenii SkurikhinAlexander Dygai
Jun 8, 2021·International Journal of Pharmaceutics·Mengning HeQingliang Yang
Jun 14, 2021·Carbohydrate Polymers·Ivy Saha, Vineet Kumar Rai
Jul 3, 2021·Polymers·Teresa BasinskaStanislaw Slomkowski
Jul 24, 2021·International Journal of Biological Macromolecules·Natallia V DubashynskayaYury A Skorik
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anca Maria JuncanFelicia Loghin
Nov 26, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Meng-Ting ChiangDe-Hao Tsai
Oct 6, 2020·ACS Applied Materials & Interfaces·Yang YuShaokang Guan
Jan 25, 2022·Journal of Agricultural and Food Chemistry·Shanshan Tie, Mingqian Tan

❮ Previous
Next ❯

Methods Mentioned

BETA
chemical modification
PCR
amidation
nanoprecipitation
xenograft
fluorescence recovery
biosensing

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Eun Ju OhSei Kwang Hahn
International Journal of Molecular Sciences
Katarína Valachová, Ladislav Šoltés
© 2022 Meta ULC. All rights reserved