Hyaluronic acid and hyaluronidase. 2 new bladder carcinoma markers

Der Urologe. Ausg. A
Stefan H HautmannVinata B Lokeshwar

Abstract

The heterogeneity of bladder cancer concerning progress of recurrence is an essential characteristic of this disease. Hyaluronic acid (HA) and its degrading enzyme hyaluronidase (HAase) are intricately associated with bladder cancer angiogenesis and metastasis. Tumor-associated HA and HAase are secreted in urine. In 513 urine specimens (261 bladder cancer patients, 252 patients without bladder cancer) and 83 bladder tissue specimens (71 bladder tumors, 12 normal bladder tissues), the accuracy of HA and HAase as tumor markers was studied. Elevated urinary HA levels (> or = 500 ng/ml), indicating a positive HA test, suggest the presence of bladder cancer regardless of tumor grade. Elevated urinary HAase levels (> or = 10 mU/mg) indicate high-grade (G2/G3) bladder cancer. The combined HA-HAase urine test showed 91% sensitivity and 84% specificity to detect bladder cancer. The HA-HAase test is equally sensitive for monitoring tumor recurrence. Immunohistochemistry (IHC) staining of HA and HAase in the G1 and G2/G3 bladder cancer specimens was significantly (p < 0.001) higher than in normal bladder tissue. HA and HAase appear to be useful markers in the diagnosis of bladder cancer. When compared with other noninvasive tests, the HA-...Continue Reading

Citations

Feb 18, 2010·Biomarkers in Medicine·Patrick VillicanaCharles J Rosser
Jan 15, 2014·Urologia·Fabrizio Dal MoroFiliberto Zattoni
Aug 23, 2020·International Journal of Molecular Sciences·Jinfen WeiHongli Du
Apr 25, 2019·Nature Reviews. Urology·Neus Martínez-BoschPilar Navarro
Jul 5, 2006·Urologic Oncology·Badrinath R Konety
Jul 16, 2013·The Journal of Organic Chemistry·Guofeng GuB Mario Pinto
Apr 2, 2009·Organogenesis·Erin L PardueAnand Ramamurthi

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