Hyaluronic acid conjugates for topical treatment of skin cancer lesions.

Science Advances
Vinu KrishnanSamir Mitragotri

Abstract

Skin cancer is one of the most common types of cancer in the United States and worldwide. Topical products are effective for treating cancerous skin lesions when surgery is not feasible. However, current topical products induce severe irritation, light-sensitivity, burning, scaling, and inflammation. Using hyaluronic acid (HA), we engineered clinically translatable polymer-drug conjugates of doxorubicin and camptothecin termed, DOxorubicin and Camptothecin Tailored at Optimal Ratios (DOCTOR) for topical treatment of skin cancers. When compared to the clinical standard, Efudex, DOCTOR exhibited high cancer-cell killing specificity with superior safety to healthy skin cells. In vivo studies confirmed its efficacy in treating cancerous lesions without irritation or systemic absorption. When tested on patient-derived primary cells and live-skin explants, DOCTOR killed the cancer with a selectivity as high as 21-fold over healthy skin tissue from the same donor. Collectively, DOCTOR provides a safe and potent option for treating skin cancer in the clinic.

References

Nov 1, 1995·The Laryngoscope·J S MasinN A Berger
Jun 1, 1996·Toxicology and Applied Pharmacology·E CorsiniC L Galli
Jul 31, 2009·PharmacoEconomics·Marjorie V NeideckerSteven R Feldman
Apr 21, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shuang CaiM Laird Forrest
Jun 24, 2010·ACS Nano·Marek GrzelczakLuis M Liz-Marzán
Oct 27, 2015·Journal of Applied Crystallography·Ingo BreßlerAndreas F Thünemann
Jan 8, 2016·The Journal of Investigative Dermatology·Victor A NeelAnna Mandinova
Jan 13, 2016·CA: a Cancer Journal for Clinicians·Mary Kay Barton
Jul 21, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·F GroeberK R Mewes
Mar 1, 2017·Dermatology Practical & Conceptual·Emily L Guo, Rajani Katta
Mar 25, 2017·Advanced Healthcare Materials·Amrita BanerjeeSamir Mitragotri
May 19, 2017·Dermatology Practical & Conceptual·Zoe ApallaDemetrios Ioannides
Aug 22, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Douglas R VogusSamir Mitragotri
Dec 21, 2017·Beilstein Journal of Organic Chemistry·Markéta BláhováJindřich Jindřich
Dec 12, 2018·Angewandte Chemie·Anusha PusuluriSamir Mitragotri
Dec 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Runhua LiuFuguo Liu
Feb 11, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Yan LiangYong Sun
Jun 5, 2020·Advanced Drug Delivery Reviews·Vinu Krishnan, Samir Mitragotri

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Software Mentioned

DOCTOR
GraphPad Prism
Efudex
Thermo
NTA
Cell Discover
Gwyddion
SASfit
GraphPad
ImageJ

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