Hyaluronic acid-decorated dual responsive nanoparticles of Pluronic F127, PLGA, and chitosan for targeted co-delivery of doxorubicin and irinotecan to eliminate cancer stem-like cells

Biomaterials
Hai WangXiaoming He

Abstract

Dual responsive nanoparticles are developed for co-delivery of multiple anticancer drugs to target the drug resistance mechanisms of cancer stem-like cells (CSCs). The nanoparticles consist of four polymers approved by the Food and Drug Administration (FDA) for medical use: Poly(d,l-lactide-co-glycolide) (PLGA), Pluronic F127 (PF127), chitosan, and hyaluronic acid (HA). By combining PLGA and PF127 together, more stable and uniform-sized nanoparticles can be obtained than using PLGA or PF127 alone. The HA is used for not only actively targeting CSCs to reduce their drug resistance due to dormancy (i.e., slow metabolism), but also replacing the commonly used poly(vinyl alcohol) as a stabilizing agent to synthesize the nanoparticles using the double-emulsion approach and to allow for acidic pH-triggered drug release and thermal responsiveness. Besides minimizing drug efflux from CSCs, the nanoparticles encapsulated with doxorubicin hydrochloride (DOX, hydrophilic) and irinotecan (CPT, hydrophobic) to inhibit the activity of topoisomerases II and I, respectively, can fight against the CSC drug resistance associated with their enhanced DNA repair and anti-apoptosis. Ultimately, the two drugs-laden nanoparticles can be used to effici...Continue Reading

References

Mar 12, 1992·International Journal of Cancer. Journal International Du Cancer·R KimK Okada
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L F Liu, J C Wang
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S Hirose, Y Suzuki
Nov 28, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y Xu, M A Villalona-Calero
Jun 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Huajian GaoLambert B Freund
Sep 23, 2006·The New England Journal of Medicine·Craig T JordanMark Noble
Sep 23, 2006·Nature Reviews. Cancer·Yves Pommier
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S NishimuraN Umesaki
Jul 3, 2007·Neoplasia : an International Journal for Oncology Research·Edmond AuzenneJim Klostergaard
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Sep 12, 2008·Nature Reviews. Cancer·Jane E Visvader, Geoffrey J Lindeman
Sep 18, 2009·Journal of Cellular Biochemistry·Candace A Gilbert, Alonzo H Ross
Jun 11, 2010·Chemistry & Biology·Yves PommierChristophe Marchand
Oct 4, 2011·The Journal of Clinical Investigation·Hasan KorkayaMax S Wicha
Jan 31, 2012·Biochemical Pharmacology·Che-Ming Jack Hu, Liangfang Zhang
Apr 5, 2012·Nanomedicine·Serguei Vinogradov, Xin Wei
Aug 1, 2010·Therapeutic Delivery·Che-Ming Jack HuLiangfang Zhang
Feb 16, 2013·Biomaterials·Shishuai SuGuangjun Nie
Apr 9, 2013·Molecular and Cellular Endocrinology·Andrew R Chin, Shizhen Emily Wang
Sep 26, 2013·Nature Reviews. Cancer·Caitriona HolohanPatrick G Johnston
Nov 26, 2013·Advanced Drug Delivery Reviews·Nicolas BertrandOmid C Farokhzad
Dec 7, 2013·ACS Applied Materials & Interfaces·Mohammad H El-DakdoukiXuefei Huang
Mar 13, 2014·Nature Communications·Ran MoZhen Gu
Jan 25, 2012·Advanced Functional Materials·Michele C JenGuillermo A Ameer
Oct 9, 2014·Angewandte Chemie·Tianmeng SunYounan Xia

❮ Previous
Next ❯

Citations

Dec 23, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Xiaodong XieLee Jia
Dec 22, 2015·International Journal of Pharmaceutics·Wenlong WangJimmy Yun
Dec 27, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Farha Masood
Sep 3, 2016·International Journal of Molecular Sciences·Panoraia I SiafakaDimitrios N Bikiaris
Nov 5, 2016·Colloids and Surfaces. B, Biointerfaces·Xingzhen ZhangGuangxi Zhai
Aug 2, 2016·Expert Opinion on Drug Delivery·Fanfei MengYoon Yeo
May 10, 2017·ACS Applied Materials & Interfaces·Wen-Qing LiSi-Yang Zheng
Oct 21, 2016·Expert Opinion on Drug Delivery·Wing-Hin LeeRamin Rohanizadeh
Dec 6, 2017·Advanced Healthcare Materials·Pradip Shahi ThakuriHossein Tavana
Aug 23, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Sai Kiran S S PindiproluVeera Venkata Satyanarayana Reddy Karri
Jan 6, 2018·Expert Opinion on Drug Delivery·Chintan BhavsarAbdelwahab Omri
Mar 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiayi PanVladimir P Torchilin
Jan 27, 2019·Drug Development and Industrial Pharmacy·Yu-Jiao XieJiang-Nan Yu
Feb 13, 2018·BioImpacts : BI·Marziyeh FathiYadollah Omidi
Dec 25, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Milad Fathi-AchacheloueiAysen Tezcaner
Oct 17, 2019·Experimental Biology and Medicine·Jennifer S WinklerMaria S Tomassone
Mar 29, 2020·Pharmaceutics·Nataša AvramovićTatjana Simić
Jun 18, 2020·Advanced Healthcare Materials·Jiangsheng XuXiaoming He
Jul 3, 2020·Chemical & Pharmaceutical Bulletin·Shintaro Fumoto, Koyo Nishida
Sep 21, 2019·Future Medicinal Chemistry·Ming-Hsien LinJia-You Fang
Aug 25, 2020·Advanced Therapeutics·Noah PacificiJamal S Lewis
Mar 7, 2017·Frontiers in Pharmacology·Binbin LiHonglian Dai
Feb 9, 2017·Journal of Experimental & Clinical Cancer Research : CR·Shoubing ZhouYanwen Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.