Hyaluronic acid decorated tacrolimus-loaded nanoparticles: Efficient approach to maximize dermal targeting and anti-dermatitis efficacy

Carbohydrate Polymers
Fan ZhuoZahid Hussain

Abstract

Nano-delivery systems have gained remarkable recognition for targeted delivery of therapeutic payload, reduced off-target effects, and improved biopharmaceutical profiles of drugs. Therefore, we aimed to fabricate polymeric nanoparticles (NPs) to deliver tacrolimus (TCS) to deeper layers of the skin in order to alleviate its systemic toxicity and improved therapeutic efficacy against atopic dermatitis (AD). To further optimize the targeting efficiency, TCS-loaded NPs were coated with hyaluronic acid (HA). Following the various physicochemical optimizations, the prepared HA-TCS-CS-NPs were tested for in vitro drug release kinetics, drug permeation across the stratum corneum, percentage of drug retained in the epidermis and dermis, and anti-AD efficacy. Results revealed that HA-TCS-CS-NPs exhibit sustained release profile, promising drug permeation ability, improved skin retention, and pronounced anti-AD efficacy. Conclusively, we anticipated that HA-based modification of TCS-CS-NPs could be a promising therapeutic approach for rationalized management of AD, particularly in children as well as in adults having steroid phobia.

Citations

Nov 16, 2019·International Journal of Molecular Sciences·Eliana B SoutoAmélia M Silva
Feb 16, 2020·Drug Delivery and Translational Research·Juliana Santos Rosa ViegasMaria Vitória Lopes Badra Bentley
Aug 21, 2020·Expert Opinion on Drug Delivery·Estefânia Vangelie Ramos CamposDaniele Ribeiro de Araujo
Nov 12, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sevgi Güngör, Emine Kahraman
Jan 25, 2021·AAPS PharmSciTech·Khushali ParekhAmirali Popat
May 30, 2020·Molecular Pharmaceutics·Mingyue CuiChenjie Xu
Jun 16, 2021·Carbohydrate Polymers·Salma A FereigMona M A Abdel-Mottaleb
Oct 26, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wei ChenZahid Hussain
Dec 23, 2021·Journal of Cosmetic Dermatology·Shruti GhosalkarPadmini Ravikumar
Jan 15, 2022·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chetna HemrajaniKamal Dua

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