Hyaluronic acid-endostatin2-alft1 (HA-ES2-AF) nanoparticle-like conjugate for the target treatment of diseases

Journal of Controlled Release : Official Journal of the Controlled Release Society
Feng SunHaining Tan

Abstract

Anti-flt1 peptide (GNQWFI, AF) specifically binds to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1), thereby inhibiting the interaction of VEGFR1 with a series of ligands. ES2 (IVRRADRAAVP) can effectively inhibit the proliferation and invasion of endothelial cells and play a key role in anti-angiogenesis. AF and ES2 peptides differ in their activity. To better exploit the advantages of both, we designed a new peptide called ES2-AF (IVRRADRAAVPGGGGGGNQWFI). Hyaluronic acid (HA) is widely used in the pharmaceutical industry because of its biodegradable and high load performance. The HA-specific cell surface receptor CD44 was highly expressed in the tumour site during the anti-tumour study. Therefore, we used HA as a modifier to chemically modify ES2-AF; it was expected that the modified compound would have preferable solubility, stronger targeting, longer half-life, and better anti-angiogenesis effects in vivo. In this study, the anti-proliferative, anti-migration and targeting activities of HA-ES2-AF in vitro were studied by MTT, ELISA, transwell and SPR assays. Meanwhile, the anti-neovascularization activity of HA-ES2-AF in vivo was studied by CAM assay, and the targeting of HA-ES2-AF to tumour tissue was studied by bi...Continue Reading

Citations

May 10, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Guangping YuShengsong Tang
Aug 8, 2019·Expert Opinion on Drug Delivery·Yu Sakurai, Hideyoshi Harashima
Nov 19, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marie RütterAyelet David
Mar 4, 2021·ACS Applied Materials & Interfaces·Qirong LiYunfeng Lin

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