Hyaluronic acid for the treatment of airway diseases in children: Little evidence for few indications

Pediatric Pulmonology
Maria Di CiccoRenato Cutrera

Abstract

Hyaluronic acid (HA) is major physiological component of the extracellular matrix, which, in its high molecular weight form (HMW-HA) has anti-inflammatory properties. The diffusion of many different medical devices for inhalation therapy containing HA has led to an increase in their prescription, also in children. Here, we systematically review the published evidence on the efficacy and safety of HA for the treatment of upper and lower airway diseases in childhood. Relevant published studies (randomized controlled trials) for the efficacy of HA inhalation in children with upper airways diseases, asthma, cystic fibrosis (CF), and non-CF bronchiectasis were searched in Pubmed, Scopus, and Web of Knowledge databases by combining the adequate Medical Subject Headings terms and keywords, with no limit for the year of publication. We identified seven relevant publications for upper airways diseases, one for asthma, and five for CF, while we found no clinical trial including children with non-CF bronchiectasis. Meta-analysis was not conducted due to the heterogeneity of the included studies. The evidence of HA efficacy in the treatment of the upper and lower airways is still limited in children. Available data suggest that inhaled HMW...Continue Reading

References

Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·P VengeR Dahl
Nov 26, 1999·American Journal of Respiratory Cell and Molecular Biology·R FortezaG E Conner
Oct 6, 2000·American Journal of Respiratory Cell and Molecular Biology·R C SavaniN Khalil
Apr 26, 2003·American Journal of Respiratory and Critical Care Medicine·Gerard M Turino, Jerome O Cantor
Jul 2, 2004·Nature Reviews. Cancer·Bryan P Toole
Jul 23, 2005·American Journal of Respiratory Cell and Molecular Biology·Aisha ZamanRashmin C Savani
Jan 20, 2006·The New England Journal of Medicine·Mark R ElkinsUNKNOWN National Hypertonic Saline in Cystic Fibrosis (NHSCF) Study Group
May 11, 2006·Experimental Lung Research·Priya P NadkarniJerome O Cantor
Dec 16, 2006·Inflammation & Allergy Drug Targets·Jerome O Cantor, Priya P Nadkarni
Aug 9, 2008·Clinical Interventions in Aging·Alberto Migliore, Mauro Granata
Jul 15, 2009·Immunological Reviews·David G Jackson
May 17, 2011·The Journal of Allergy and Clinical Immunology·Jiurong LiangPaul W Noble
May 17, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Frances E Lennon, Patrick A Singleton
Oct 25, 2011·Respiratory Medicine·Fiona Kellett, Niven M Robert
May 9, 2012·Handbook of Experimental Pharmacology·Luigi AllegraGiuseppe Petrigni
Mar 27, 2013·International Journal of Immunopathology and Pharmacology·A MacchiE Digilio
Aug 1, 2013·American Journal of Respiratory and Critical Care Medicine·Pamela J McShaneMary E Strek
Mar 25, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Maurizio Di CiccoCarla Colombo
Mar 10, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ahmed LazrakSadis Matalon
Nov 7, 2015·Advanced Drug Delivery Reviews·Jiurong LiangPaul W Noble
Jan 10, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stavros GarantziotisLorenzo Drago
Jun 1, 2016·International Journal of Pediatric Otorhinolaryngology·Casale ManueleSalvinelli Fabrizio
Aug 3, 2016·International Journal of Immunopathology and Pharmacology·Sara TorrettaLorenzo Pignataro
Sep 11, 2016·The Journal of Biological Chemistry·Stavros GarantziotisJohn W Hollingsworth
Oct 4, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·S TorrettaL Pignataro
Oct 8, 2016·Respiratory Research·Adelaida LamasStavros Garantziotis
Jul 25, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Alberto Vito MarcuzzoGiancarlo Tirelli
Oct 28, 2017·International Journal of Chronic Obstructive Pulmonary Disease·Jerome CantorGerard Turino
Feb 20, 2020·Carbohydrate Research·Alexander Huynh, Ronny Priefer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

International Journal of Pediatric Otorhinolaryngology
Casale ManueleSalvinelli Fabrizio
Cells
Luis Máiz Carro, Miguel A Martínez-García
Wounds : a Compendium of Clinical Research and Practice
Malgorzata LitwiniukTomasz Grzela
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Rafaela-Maria KavasiDragana Nikitovic
© 2022 Meta ULC. All rights reserved