Hyaluronic acid functionalized nanoparticles loaded with IR780 and DOX for cancer chemo-photothermal therapy

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Cátia G AlvesIlídio J Correia

Abstract

IR780 is a near infrared (NIR) dye with a huge potential to be applied in cancer phototherapy and imaging. However, IR780 poor water solubility and acute cytotoxicity limit its direct use in cancer theragnostic. Herein, a novel Hyaluronic acid (HA)-based amphiphilic polymer was used, for the first time, in the preparation of polymeric nanoparticles (HPN) encapsulating IR780 aimed to be applied in breast cancer therapy. Furthermore, HPN co-encapsulating IR780 and Doxorubicin (DOX) were also produced in order to further enhance the therapeutic effectiveness of this nanoformulation. The results revealed that HPN were able to successfully encapsulate IR780 (IR-HPN) and the IR780-DOX combination (IR/DOX-HPN). Furthermore, the encapsulation of IR780 in HPN improved its absorption at 808 nm by about 2.2-fold, thereby enhancing its photothermal potential, as well as its cytocompatibility. The 2D in vitro cell uptake studies demonstrated that the nanostructures displayed a higher internalization by breast cancer cells than by normal cells. In addition, the assays performed in 3D in vitro models of breast cancer revealed that HPN can penetrate into spheroids. Furthermore, the 3D in vitro studies also demonstrated that the combined applic...Continue Reading

Citations

Jul 3, 2019·Pharmaceutics·Kibeom KimJa-Hyoung Ryu
Jan 30, 2020·Advanced Healthcare Materials·Miguel M LeitãoIlídio J Correia
Jun 30, 2019·Biomaterials Science·Duarte de Melo-DiogoIlídio J Correia
Jun 20, 2020·Nanomedicine·Inês MóIlídio J Correia
Dec 8, 2020·Journal of Pharmaceutical and Biomedical Analysis·Jianmei WangXiaowei Dong
Sep 11, 2020·Acta Biomaterialia·Ariana S C GonçalvesIlídio J Correia
Jan 2, 2021·International Journal of Molecular Sciences·Daniel N SilvaAndré F Moreira
Feb 15, 2021·Colloids and Surfaces. B, Biointerfaces·Huan ChenLiangke Zhang
Mar 27, 2021·International Journal of Pharmaceutics·Ivo J SabinoDuarte de Melo-Diogo
Oct 18, 2021·Macromolecular Bioscience·Francesca Della SalaAssunta Borzacchiello
Nov 30, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiahe BaoYuanqiang Guo
Nov 30, 2021·Biotechnology and Bioengineering·Ariana S C GonçalvesIlídio J Correia

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