Hyaluronic acid ion-pairing nanoparticles for targeted tumor therapy

Journal of Controlled Release : Official Journal of the Controlled Release Society
Wenhao LiTao Gong

Abstract

Hyaluronic acid (HA)-based doxorubicin (DOX) nanoparticles (HA-NPs) were fabricated via ion-pairing between positively charged DOX and negatively charged HA, which displayed near-spherical shapes with an average size distribution of 180.2nm (PDI=0.184). Next, HA-NPs were encapsulated in liposomal carriers to afford HA-based DOX liposomes (HA-LPs), which also showed near-spherical morphology with an average size of 130.5nm (PDI=0.201). HA-NPs and HA-LPs displayed desirable sustained-release profiles compared to free DOX, and moreover, HA-LPs were proven to prevent premature release of DOX from HA-NPs. Cell based studies demonstrated HA-NPs and HA-LPs were selectively taken up by CD44(+) tumor cells, and DOX was released intracellularly to target the cell nuclei. Both HA-NPs and HA-LPs showed comparable levels of penetration efficiency in tumor spheroids. In vivo studies revealed that HA-NPs and HA-LPs significantly prolonged the blood circulation time of DOX, decreased accumulation in the normal tissues and enriched drugs into the tumors. Furthermore, HA-NPs and HA-LPs greatly enhanced therapeutic efficacy of DOX in tumor-bearing mice and minimized systemic toxicity against vital organs. In sum, HA-NPs and HA-LPs represent promi...Continue Reading

References

Oct 1, 1991·The Journal of Experimental Medicine·M S SyI Stamenkovic
Jun 10, 1983·Science·R N Feinberg, D C Beebe
Sep 30, 1999·Bioconjugate Chemistry·Y Luo, G D Prestwich
Mar 1, 2000·Molecular Pathology : MP·S GoodisonD Tarin
Nov 22, 2001·The Journal of Biological Chemistry·Markku I TammiEva A Turley
Mar 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M St'astnýB Ríhová
Dec 18, 2002·Critical Reviews in Clinical Laboratory Sciences·David NaorYoram Faitelson
Dec 30, 2003·International Journal of Cancer. Journal International Du Cancer·Dan Peer, Rimona Margalit
Jul 2, 2004·Nature Reviews. Cancer·Bryan P Toole
Dec 18, 2007·International Journal of Pharmaceutics·Jun-ichi YokoeToshikiro Kimura
Jun 16, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Madaswamy S MuthuSanjay Singh
Sep 18, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eun Ju OhSei Kwang Hahn
Dec 10, 2009·Molecular Pharmaceutics·Shyh-Dar Li, Stephen B Howell
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Che-Ming J HuLiangfang Zhang
Oct 11, 2011·Advanced Drug Delivery Reviews·Sandrine DufortJean-Luc Coll
Nov 15, 2011·Colloids and Surfaces. B, Biointerfaces·Ki Young ChoiKinam Park
Dec 21, 2012·Journal of the American Chemical Society·Erlei JinMaciej Radosz
Jul 9, 2013·International Journal of Pharmaceutics·Pengfei XuYaping Li
Aug 21, 2013·Molecular Pharmaceutics·Jing ZhouTao Gong
Sep 26, 2013·Pharmaceutical Research·Peng ZouDuxin Sun
Oct 29, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shanthi GaneshMansoor M Amiji
Nov 30, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhiting DengHairong Zheng
Mar 8, 2014·Journal of Pharmaceutical Sciences·Wenyi ZhengZongning Yin
Feb 11, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chenchen YangXiqun Jiang
May 3, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Theodora KaramanidouCostas Kiparissides
Aug 26, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Yoonjee ParkJoyce Y Wong

❮ Previous
Next ❯

Citations

Jul 31, 2018·Drug Development and Industrial Pharmacy·Chuchu ZhouTao Gong
May 8, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Soeun GimMartina Delbianco
May 8, 2019·Journal of Liposome Research·Panikchar WichayapreecharChadarat Ampasavate
Feb 25, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xue ChenYao Fu
Sep 15, 2017·Journal of Drug Targeting·Ummarah KanwalAbida Raza
Nov 29, 2016·Expert Opinion on Drug Delivery·Mariana Silva OliveiraGuilherme Carneiro
Sep 13, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ting GongZhirong Zhang
May 26, 2018·Journal of Biomaterials Science. Polymer Edition·Shuang DengXu Ye
Aug 8, 2019·Expert Opinion on Drug Delivery·Yu Sakurai, Hideyoshi Harashima
Aug 6, 2019·International Journal of Biological Macromolecules·Dalia El BaiharyOmaima A Sammour
Dec 5, 2020·International Journal of Molecular Sciences·Yanzhen SunHao Hu
Oct 1, 2019·Nanoscale Advances·Kurt D Ristroph, Robert K Prud'homme
Apr 3, 2021·International Journal of Pharmaceutics·Kangkang LiXuehong Chen
Jun 20, 2021·Macromolecular Bioscience·Yining NiuYao Fu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.