Hyaluronic acid-modified betamethasone encapsulated polymeric nanoparticles: fabrication, characterisation, in vitro release kinetics, and dermal targeting

Drug Delivery and Translational Research
Manisha PandeyZahid Hussain

Abstract

Atopic dermatitis (AD) is a chronically relapsing eczematous skin disease characterised by frequent episodes of rashes, severe flares, and inflammation. Till date, there is no absolute therapy for the treatment of AD; however, topical corticosteroids (TCs) are the majorly prescribed class of drugs for the management of AD in both adults and children. Though, topical route is most preferable; however, limited penetration of therapeutics across the startum cornum (SC) is one of the major challenges for scientists. Therefore, the present study was attempted to fabricate a moderate-potency TC, betamethasone valerate (BMV), in the form of chitosan nanoparticles (CS-NPs) for optimum dermal targeting and improved penetration across the SC. To further improve the targeting efficiency of BMV and to potentiate its therapeutic efficacy, the fabricated BMV-CS-NPs were coated with hyaluronic acid (HA). The prepared NPs were characterised for particle size, zeta potential, polydispersity index (PDI), entrapment efficiency, loading capacity, crystallinity, thermal behaviour, morphology, in vitro release kinetics, drug permeation across the SC, and percentage of drug retained into various skin layers. Results showed that optimised HA-BMV-CS-NP...Continue Reading

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Citations

Jul 18, 2019·Expert Opinion on Drug Delivery·Yang ChenShengnan Meng
Apr 10, 2019·Polymers·Arianna FallacaraSilvia Vertuani
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Jan 25, 2021·AAPS PharmSciTech·Khushali ParekhAmirali Popat
Aug 21, 2021·Journal of Agricultural and Food Chemistry·Xiao-Long LiBao Zhang
Oct 29, 2021·Journal of Biomedical Nanotechnology·Tianjiao HanHongzheng Fu
Nov 2, 2020·European Journal of Pharmacology·Arya Kadukkattil RamanunnyNarendra Kumar Pandey

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Methods Mentioned

BETA
scanning electron microscopy
dynamic dialysis

Software Mentioned

SPSS

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