Hyaluronic-acid-modified lipid-polymer hybrid nanoparticles as an efficient ocular delivery platform for moxifloxacin hydrochloride

International Journal of Biological Macromolecules
Dan LiuJuan Li

Abstract

To improve the ocular bioavailability of the strongly hydrophilic moxifloxacin hydrochloride, hyaluronic-acid-modified lipid-polymer hybrid nanoparticles (HA-LCS-NPs) were designed and characterized. An in vivo precorneal retention study in rabbits showed that the mean residence time (MRT) and area under the curve (AUC0-6h) of HA-LCS-NPs were up to 6.74-fold and 4.29-fold higher than those of the commercial product. An in vitro corneal penetration study in rabbits demonstrated that the apparent permeability coefficient (Papp) of HA-LCS-NPs was increased by 3.29-fold compared to the commercial product, which might be observed because the surface-modified hyaluronic acid could expedite the cellular uptake of HA-LCS-NPs by receptor-mediated endocytosis. Moreover, in contrast with other formulations, the results of ex vivo fluorescence imaging showed that the fluorescence intensity was higher in the cornea and conjunctiva after administration of HA-LCS-NPs. Finally, an ocular irritation study indicated that HA-LCS-NPs displayed excellent ocular tolerance. In summary, the hyaluronic-acid-modified lipid-polymer hybrid nanoparticles with multifunctional properties might be a promising ocular drug delivery system for prolonged precorne...Continue Reading

Citations

Nov 9, 2019·Expert Opinion on Drug Delivery·Prashant GargGirdhari Roy
Dec 12, 2019·Advances in Therapy·Marcelo Luís OcchiuttoAnastasios G Konstas
Aug 5, 2020·Drug Delivery and Translational Research·Malobika Chakravarty, Amisha Vora
Dec 29, 2020·Frontiers in Bioengineering and Biotechnology·Haozhe YuYun Feng
Feb 7, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Clotilde JumelleReza Dana
Mar 7, 2021·Carbohydrate Polymers·Gloria Huerta Ángeles, Kristina Nešporová
Sep 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ayeskanta MohantyIn-Kyu Park
Apr 30, 2021·Carbohydrate Polymers·Xiaodan ZhangQiang Zhu
Jun 14, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ridhdhi S DaveHeather Sheardown
Jul 14, 2021·Expert Opinion on Drug Delivery·Axel KattarCarmen Alvarez-Lorenzo
Aug 8, 2021·Materials·Melitini KoutsovitiMarilena Vlachou

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