Hyaluronic Acid-Modified Multifunctional Q-Graphene for Targeted Killing of Drug-Resistant Lung Cancer Cells

ACS Applied Materials & Interfaces
Yanan LuoDan Du

Abstract

Considering the urgent need to explore multifunctional drug delivery system for overcoming multidrug resistance, we prepared a new nanocarbon material Q-Graphene as a nanocarrier for killing drug-resistant lung cancer cells. Attributing to the introduction of hyaluronic acid and rhodamine B isothiocyanate (RBITC), the Q-Graphene-based drug delivery system was endowed with dual function of targeted drug delivery and fluorescence imaging. Additionally, doxorubicin (DOX) as a model drug was loaded on the surface of Q-Graphene via π-π stacking. Interestingly, the fluorescence of DOX was quenched by Q-Graphene due to its strong electron-accepting capability, and a significant recovery of fluorescence was observed, while DOX was released from Q-Graphene. Because of the RBITC labeling and the effect of fluorescence quenching/restoring of Q-Graphene, the uptake of nanoparticles and intracellular DOX release can be tracked. Overall, a highly promising multifunctional nanoplatform was developed for tracking and monitoring targeted drug delivery for efficiently killing drug-resistant cancer cells.

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Citations

May 29, 2016·Advanced Drug Delivery Reviews·Kai YangZhuang Liu
Jul 28, 2016·ACS Applied Materials & Interfaces·Xiaoli CaiYuehe Lin
Sep 3, 2016·International Journal of Molecular Sciences·Panoraia I SiafakaDimitrios N Bikiaris
Feb 6, 2017·ACS Applied Materials & Interfaces·Xiaoli CaiYuehe Lin
Apr 13, 2017·Biomaterials Science·Shine AugustineBansi D Malhotra
May 10, 2017·Biomacromolecules·Zhixiang CaiFengsong Cong
Jul 25, 2018·Advanced Materials·Zhanjun GuYuliang Zhao
Mar 28, 2019·Frontiers in Pharmacology·Debabrata MaitiKai Yang
May 20, 2017·Frontiers in Surgery·Nikolaos PatelisChris Klonaris
Aug 8, 2019·Expert Opinion on Drug Delivery·Yu Sakurai, Hideyoshi Harashima
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manuela CurcioGiuseppe Cirillo
Dec 17, 2020·Frontiers in Molecular Biosciences·Gennaro SanitàAnnalisa Lamberti
Apr 16, 2021·Frontiers in Cell and Developmental Biology·Yuan MaGe Zhang
Jun 18, 2021·Nano-micro Letters·Shruti Rawal, Mayur Patel
Jul 9, 2021·Advances in Colloid and Interface Science·Da LiClaire Mangeney

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