Hyaluronic acid modified pH-sensitive liposomes for targeted intracellular delivery of doxorubicin

Journal of Liposome Research
Shivani Rai PaliwalS P Vyas

Abstract

Surface-modified pH-sensitive liposomal system may be useful for intracellular delivery of chemotherapeutics. Achieving site-specific targeting with over-expressed hyaluronic acid (HA) receptors along with using pH sensitive liposome carrier for intracellular drug delivery was the aim of this study. Stealth HA-targeted pH-sensitive liposomes (SL-pH-HA) were developed and evaluated to achieve effective intracellular delivery of doxorubicin (DOX) vis-a-vis enhanced antitumor activity. The in vitro release studies demonstrated that the release of DOX from SL-pH-HA was pH-dependent, i.e. faster at mildly acidic pH ∼5, compared to physiological pH ∼7.4. SLpH-HA was evaluated for their cytotoxicity potential on CD44 receptor expressing MCF-7 cells. The half maximal inhibitory concentration (IC50) of SL-pH-HA and SL-HA were about 1.9 and 2.5 μM, respectively, after 48 h of incubation. The quantitative uptake study revealed higher localization of targeted liposomes in the receptor positive cells, which was further confirmed by fluorescent microscopy. The antitumor efficacy of the DOX-loaded HA-targeted pH-sensitive liposomes was also verified in a tumor xenograft mouse model. DOX was efficiently delivered to the tumor site by active ta...Continue Reading

References

Oct 15, 1978·Analytical Biochemistry·D W FryI D Goldman
Jan 1, 1985·FEBS Letters·R M StraubingerD Papahadjopoulos
Jan 18, 1993·Biochimica Et Biophysica Acta·M S WebbP L Steponkus
Apr 1, 1997·Molecular Pathology : MP·Z Rudzki, S Jothy
Jul 15, 1998·International Journal of Cancer. Journal International Du Cancer·C ZengI Stamenkovic
Jul 20, 1999·Experimental and Molecular Pathology·A Herrera-Gayol, S Jothy
Sep 30, 1999·Bioconjugate Chemistry·Y Luo, G D Prestwich
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H MaedaK Hori
Feb 15, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Jul 13, 2004·Drug Development and Industrial Pharmacy·A ManosroiJ Manosroi
Mar 4, 2005·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·L Harivardhan Reddy, R S R Murthy
Aug 18, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Luc Wasungu, Dick Hoekstra
Sep 18, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Samir TurakhiaGovindasamy Ilangovan
Dec 11, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Awesh Kumar YadavGovind Prasad Agrawal
Jul 8, 2008·Journal of Drug Targeting·Shivani RaiS P Vyas
Jan 15, 2010·Methods in Molecular Biology·Tamer A Elbayoumi, Vladimir P Torchilin
Nov 16, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Peijian SunZhihua Gan
Nov 26, 2010·Macromolecular Bioscience·Cheng ZhengLiyan Qiu
Oct 12, 2011·Journal of the American Chemical Society·Jin-Zhi DuJun Wang

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Citations

Sep 3, 2016·International Journal of Molecular Sciences·Panoraia I SiafakaDimitrios N Bikiaris
May 23, 2017·Therapeutic Delivery·Claudia Zylberberg, Sandro Matosevic
Oct 31, 2019·Journal of Liposome Research·Calvin A OmoloThirumala Govender
Feb 16, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Y Lee, D H Thompson
Feb 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Song ShenLin Wu
Jul 29, 2020·Journal of Liposome Research·Shivani SarafSanjay K Jain
Apr 10, 2019·Polymers·Jin Hong KimYong Yeon Jeong
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Umut Can OzAsuman Bozkir
May 7, 2021·International Journal of Nanomedicine·Yufei FengYanhong Wang
Nov 18, 2020·Current Pharmaceutical Design·Shivani Rai PaliwalRishi Paliwal

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