Abstract
Hyaluronic acid (HA), a component of the extracellular matrix, affects gastrointestinal epithelial proliferation in injury models, but its role in normal growth is unknown. We sought to determine the effects of exogenous HA on intestinal and colonic growth by intraperitoneal injection of HA twice a week into C57BL/6 mice from 3 to 8 wk of age. Similarly, to determine the effects of endogenous HA on intestinal and colonic growth, we administered PEP-1, a peptide that blocks the binding of HA to its receptors, on the same schedule. In mice treated with exogenous HA, villus height and crypt depth in the intestine, crypt depth in the colon, and epithelial proliferation in the intestine and colon were increased. In mice treated with PEP-1, intestinal and colonic length were markedly decreased and crypt depth and villus height in the intestine, crypt depth in the colon, and epithelial proliferation in the intestine and colon were decreased. Administration of HA was associated with increased levels of EGF (intestine) and IGF-I (colon), whereas administration of PEP-1 was associated with decreased levels of IGF-I (intestine) and epiregulin (colon). Exogenous HA increases intestinal and colonic epithelial proliferation, resulting in hyp...Continue Reading
References
Jul 1, 1991·The Journal of Investigative Dermatology·R TammiM Tammi
Oct 1, 1994·Current Opinion in Cell Biology·L ShermanH Ponta
Apr 14, 1995·Journal of Chromatography. a·N K KaramanosA Hjerpe
Jul 1, 1996·Gastroenterology·M RieglerE Wenzl
Nov 15, 1996·The Journal of Clinical Investigation·C M McKeeP W Noble
Feb 1, 1997·Gastroenterology·K OhnedaP K Lund
Mar 21, 1997·The Journal of Biological Chemistry·C M McKeeP W Noble
Jul 1, 1997·Journal of Internal Medicine·J R FraserU B Laurent
Dec 30, 1999·Nature Genetics·J JensenO D Madsen
Sep 20, 2000·The Journal of Experimental Medicine·M E MummertA Takashima
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Naoki ItanoKoji Kimata
Mar 30, 2002·The Journal of Biological Chemistry·John F Kuemmerle, Huiping Zhou
Jul 5, 2002·The Journal of Nutrition·Elizabeth M DahlyDenise M Ney
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melanie B GillinghamDenise M Ney
Sep 5, 2003·The Journal of Biological Chemistry·Alana K MajorsScott A Strong
Jan 16, 2004·The Journal of Biological Chemistry·Naoki ItanoKoji Kimata
May 15, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Andrew W KnottBrad W Warner
Sep 4, 2004·Biochemical Pharmacology·Peter Prehm, Udo Schumacher
Oct 26, 2005·Nature Medicine·Dianhua JiangPaul W Noble
Oct 28, 2005·The Journal of Nutrition·Sangita G MuraliDenise M Ney
Jul 11, 2006·European Journal of Cell Biology·Robert SternKazuki N Sugahara
Sep 6, 2006·Gastroenterology·Masayuki FukataMaria T Abreu
Jan 4, 2007·The Journal of Clinical Investigation·Sarah L BrownThaddeus S Stappenbeck
Apr 3, 2007·The Journal of Biological Chemistry·Kristen R TaylorRichard L Gallo
Sep 8, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·J G SimmonsP K Lund
Sep 15, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Christopher M DekaneyMichael A Helmrath
Feb 28, 2008·Current Opinion in Gastroenterology·William F Stenson
Oct 16, 2008·Gastroenterology·Colm B CollinsJesús Rivera-Nieves
Jan 2, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Aaron P GarrisonMichael A Helmrath
Sep 8, 2009·Gastroenterology·Ling ZhengWilliam F Stenson
Oct 8, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert S FlynnJohn F Kuemmerle
Nov 3, 2009·Gastroenterology·Luke A J O'Neill
Nov 1, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Terrence E RiehlWilliam F Stenson
Nov 22, 2011·PloS One·Jeffrey J DehmerMichael A Helmrath
Citations
Nov 7, 2015·Advanced Drug Delivery Reviews·Jiurong LiangPaul W Noble
Jul 21, 2015·Clinical Biochemistry·Manuela G NeumanRadu Nanau
Jul 30, 2015·Experimental Cell Research·Piia TakabeSanna Pasonen-Seppänen
May 6, 2015·Pediatric Research·Brittany KnipsteinDavid A Rudnick
Mar 15, 2018·Drug Metabolism and Personalized Therapy·Reenu Anne JoyPrasanth S Ariyannur
Jul 17, 2012·Applied and Environmental Microbiology·Wayne YoungGerald W Tannock
Jan 5, 2013·Current Opinion in Gastroenterology·William F Stenson
Sep 26, 2019·Scientific Reports·Dilip K MalipatlollaCecilia Bull
Jun 17, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Terrence E RiehlWilliam F Stenson
Jul 21, 2020·JCI Insight·Xiao ZhangNan Gao
Oct 28, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Terrence E RiehlWilliam F Stenson
Apr 17, 2013·The Journal of Biological Chemistry·Shradha S KhuranaJason C Mills
May 16, 2020·Frontiers in Immunology·Yeojung Kim, Carol A de la Motte
Aug 28, 2020·Scientific Reports·Maria Letizia MancaMaria Manconi
Sep 6, 2019·Molecular Cancer Therapeutics·Sarbjeet MakkarWilliam F Stenson
Feb 9, 2021·Frontiers in Immunology·William F Stenson, Matthew A Ciorba
Apr 4, 2021·International Journal of Molecular Sciences·Aditya KaulSundeep G Keswani
Jul 3, 2021·Nutrients·Franziska BayerChristoph Reinhardt
Jul 3, 2021·Regenerative Biomaterials·Hongqing ChenTao Xu
Jul 3, 2021·Nutrients·Hala ChaabanFlorea Lupu
Jul 20, 2021·Biomaterials·S RezakhaniM P Lutolf
Jul 25, 2021·International Journal of Molecular Sciences·Felix HofmannJoerg Galle
Jul 20, 2019·Carbohydrate Polymers·Alexandro B de SouzaMaria Helena A Santana