Hyaluronic acid tethered pH-responsive alloy-drug nanoconjugates for multimodal therapy of glioblastoma: An intranasal route approach

Materials Science & Engineering. C, Materials for Biological Applications
Abhijeet PandeyKrutika Sawant

Abstract

In the present investigation, FePt alloy nanoparticles were synthesized with controlled size and elemental composition followed by surface modification using (3-Aminopropyl) triethoxysilane (APTES). Lenalidomide was covalently bound to FePt-NH2 by pH sensitive hydrazone bonding. Hyaluronic acid was conjugated to amino groups of APTES while lactoferrin (Lf) was directly conjugated to excess carboxylic group present on hyaluronic acid (HA) to form surface modified pH sensitive alloy-drug nanoconjugates (SPANs). The multifunctional nanoconjugates were characterized and evaluated using extensive in vitro and in vivo techniques. The nanoconjugates demonstrated excellent heating ability on exposure to alternating magnetic field and near-infrared laser irradiation. The acidic microenvironment of lysozome triggered release of LND from SPANs. Owing to leaching of Fe and Pt contents, SPANs demonstrated ability to generate reactive oxygen species (ROS) in U87MG cell line which further enhanced therapeutic effect of SPANs. Significant difference in cell viability suppression was observed in in vitro photothermal, chemo-photothermal and chemo-magnetophotothermal killing of cancer cells using SPANs in U87MG cell lines. Significant difference...Continue Reading

Citations

Aug 14, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Steven ZanganehMorteza Mahmoudi
Jul 17, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Georgios P SkandalakisConstantinos G Hadjipanayis
Mar 30, 2020·Drug Delivery and Translational Research·Prashant G UpadhayaVandana B Patravale
Dec 10, 2020·Pharmaceutics·Manuela CurcioFrancesca Iemma
Mar 27, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Namdev DhasTejal Mehta
May 26, 2021·Colloids and Surfaces. B, Biointerfaces·Ruby Gupta, Deepika Sharma
Jan 11, 2022·Nanomedicine·Dhruba DharJyotirmoy Chatterjee

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