Hyaluronic acid/polyethylene glycol nanoparticles for controlled delivery of mitoxantrone

Artificial Cells, Nanomedicine, and Biotechnology
Azam SargaziMostafa Heidari Majd

Abstract

Hyaluronic acid (HA) has inherent ability to target the CD44 receptors and internalize into tumour cells via receptor-mediated endocytosis. Therefore, conjugation of this natural linear polysaccharide to polymeric NPs or micelles, as one of the most promising approaches, could be useful for future clinical applications such as drug delivery. Accordingly, we report on the synthesis of mitoxantrone (MTX)-conjugated polymeric nanoparticles (NPs) composed of polyethylene glycol-HA (PEG-HA) for MTX delivery toward special tumour cells. To determine the size of the polymeric NPs, field emission scanning electron microscopy (FESEM) and particle size analyzer system Zetasizer_nanoZS were employed. The in vitro cytotoxicity analysis of MTX-loaded HA-PEG NPs and free MTX against two cell lines with different levels of CD44 expression (MDA-MB-231 (very high) and MCF-7 (low) was conducted by MTT assay. Also, computational molecular docking was employed to study in detail the active site residues and the critical interactions between HA-EDA-PEG-EDA-MTX NPs and CD44 receptor. The particle size analysis and electron microscopy showed the average size of polymeric NPs less than 350 nm. FT-IR spectrophotometry analysis and also NMR confirmed th...Continue Reading

References

Sep 23, 2000·Nature·P Carmeliet, R K Jain
Dec 9, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jenifer L JohnsonImran Ahmad
Feb 3, 2007·Journal of Computational Chemistry·Ruth HueyDavid S Goodsell
Feb 13, 2007·Nature Structural & Molecular Biology·Suneale BanerjiDavid G Jackson
Sep 29, 2009·Biomaterials·Ki Young ChoiSeo Young Jeong
Oct 24, 2009·Journal of Pharmaceutical and Biomedical Analysis·Guohua An, Marilyn E Morris
Sep 29, 2011·International Journal of Pharmaceutics·Yanhua LiuZhonggui He
Feb 18, 2012·Annual Review of Physiology·Joseph A Mindell
Jan 9, 2013·Journal of Drug Targeting·Mostafa Heidari MajdYadollah Omidi
Feb 6, 2013·Journal of Chemical Information and Modeling·David Ryan KoesCarlos J Camacho
Feb 26, 2013·Colloids and Surfaces. B, Biointerfaces·Mostafa Heidari MajdYadollah Omidi
Apr 3, 2013·Archives of Toxicology·Luciana Grazziotin RossatoFernando Remião
Jan 18, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yinan ZhongZhiyuan Zhong
May 9, 2015·Frontiers in Immunology·Andre R JordanVinata B Lokeshwar
Mar 26, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Mostafa Heidari MajdAzam Sargazi
Jun 28, 2016·Journal of Molecular Modeling·Tin Trung NguyenMai Suan Li
Sep 30, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Yong HuangBo Huang
Oct 6, 2016·Carbohydrate Polymers·Wen Jen LinMing-Jium Shieh
Oct 22, 2016·Advanced Pharmaceutical Bulletin·Hassan Mansouri-TorshiziMostafa Heidari Majd

❮ Previous
Next ❯

Citations

Jun 21, 2020·Antibiotics·Muhammad IdreesAyesha Rahman
Aug 8, 2019·Expert Opinion on Drug Delivery·Yu Sakurai, Hideyoshi Harashima
Dec 12, 2020·Experimental Hematology & Oncology·Hanxiao XuAiguo Liu
Nov 6, 2020·International Journal of Nanomedicine·Zhiwen CaoYuanyan Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.