Hyaluronidase for cervical ripening and induction of labour.

The Cochrane Database of Systematic Reviews
J KavanaghJ Thomas

Abstract

Dilatation and effacement of the cervix are not only a result of uterine contractions, but are also dependent upon ripening processes within the cervix. The cervix is a fibrous organ composed principally of hyaluronic acid, collagen and proteoglycan. Hyaluronic acid increases markedly after the onset of labour. An increase in the level of hyaluronic acid is associated with an increase in tissue water content. Cervical ripening during labour is characterised by changes of the cervix and an increased water content. Cervical injection of hyaluronidase was postulated to increase cervical ripening. This is one of a series of reviews of methods of cervical ripening and labour induction using standardised methodology. To determine the effects of hyaluronidase for third trimester cervical ripening or induction of labour in comparison with other methods of induction of labour. We searched the Cochrane Pregnancy and Childbirth Group Trials Register (January 2006) and bibliographies of relevant papers. Clinical trials of hyaluronidase for third trimester cervical ripening or labour induction. A strategy was developed to deal with the large volume and complexity of trial data relating to labour induction. This involved a two-stage method o...Continue Reading

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Citations

Jun 19, 2001·The Cochrane Database of Systematic Reviews·E Hutton, E Mozurkewich
Nov 1, 2001·The Cochrane Database of Systematic Reviews·J ThomasJ Kavanagh
Jun 19, 2001·The Cochrane Database of Systematic Reviews·L French
Mar 2, 2013·The Cochrane Database of Systematic Reviews·Jannet J H BakkerJoris A M van der Post
Jun 14, 2014·The Cochrane Database of Systematic Reviews·Zarko AlfirevicAndrew Weeks
Oct 12, 2010·The Cochrane Database of Systematic Reviews·G Justus HofmeyrCynthia Pileggi
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Oct 29, 2011·BMC Pregnancy and Childbirth·Ellen L MozurkewichKristie L Keeton
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Oct 13, 2009·The Cochrane Database of Systematic Reviews·Zarko AlfirevicTherese Dowswell
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Marta JozwiakMichel Boulvain
Jun 20, 2014·The Cochrane Database of Systematic Reviews·Jane ThomasAnthony J Kelly
Oct 17, 2017·The Cochrane Database of Systematic Reviews·Caroline A SmithHannah G Dahlen
Jul 25, 2013·The Cochrane Database of Systematic Reviews·Anthony J KellyJane Thomas
Dec 6, 2016·The Cochrane Database of Systematic Reviews·Arpita GhoshAnthony J Kelly
Nov 3, 2017·The Journal of Obstetrics and Gynaecology Research·Jila AgahSedigheh Borna
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Oct 30, 2003·The Cochrane Database of Systematic Reviews·C A Smith
Jul 22, 2005·The Cochrane Database of Systematic Reviews·J KavanaghJ Thomas
Sep 9, 2021·Archives of Gynecology and Obstetrics·Ryan ChowWarren G Foster

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