Hyaluronidase increases the duration of mepivacaine in inferior alveolar nerve blocks

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Anna Carolina Ratto Tempestini HorlianaMaria Aparecida Borsatti

Abstract

To evaluate the duration of the effect of mepivacaine when hyaluronidase is injected immediately prior to the end of pulpal anesthesia. Forty bilateral, symmetrical third molar surgeries were performed in 20 healthy patients. Inferior alveolar nerve block was induced using 2.8 mL 2% mepivacaine with epinephrine. Hyaluronidase (75 turbidity-reducing units) or a placebo was injected 40 minutes after the beginning of pulpar anesthesia (randomized and double-blind trial). The duration of effect in the pulpal and gingival tissues was evaluated by response to painful electrical stimuli applied to the adjacent premolar, and by mechanical stimuli (pin prick) to the vestibular gingiva, respectively. In both tissues, the duration of anesthetic effect with hyaluronidase was longer (P < .01) than with the placebo. Hyaluronidase increases the duration of mepivacaine in inferior alveolar nerve blocks.

References

Nov 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J Sarvela, P Nikki
Dec 1, 1986·Anesthesia and Analgesia·J M NicollM James
Oct 1, 1983·The Journal of the American Dental Association·J T Jastak, J A Yagiela
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Apr 20, 2004·Journal of Cataract and Refractive Surgery·Fahad QuhillRichard B Packard
Jul 1, 2005·Arthritis Research & Therapy·Hafida El HajjajiDaniel-Henri Manicourt

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Citations

Mar 1, 1986·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·C O Taylor, J B Carter
Dec 20, 2019·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Anna Carolina Ratto Tempestini-HorlianaMaria Aparecida Borsatti

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